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Diagnostics 2015, 5(3), 296-317; doi:10.3390/diagnostics5030296

Hybrid Imaging for Patient-Specific Dosimetry in Radionuclide Therapy

Department of Medical Radiation Physics, Lund University, 221 85 Lund, Sweden
These authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Andreas Kjaer
Received: 2 June 2015 / Revised: 29 June 2015 / Accepted: 1 July 2015 / Published: 10 July 2015
(This article belongs to the Collection Hybrid Imaging in Medicine)
View Full-Text   |   Download PDF [3073 KB, uploaded 10 July 2015]   |  

Abstract

Radionuclide therapy aims to treat malignant diseases by systemic administration of radiopharmaceuticals, often using carrier molecules such as peptides and antibodies. The radionuclides used emit electrons or alpha particles as a consequence of radioactive decay, thus leading to local energy deposition. Administration to individual patients can be tailored with regards to the risk of toxicity in normal organs by using absorbed dose planning. The scintillation camera, employed in planar imaging or single-photon emission computed tomography (SPECT), generates images of the spatially and temporally varying activity distribution. Recent commercially available combined SPECT and computed tomography (CT) systems have dramatically increased the possibility of performing accurate dose planning by using the CT information in several steps of the dose-planning calculation chain. This paper discusses the dosimetry chain used for individual absorbed-dose planning and highlights the areas where hybrid imaging makes significant contributions. View Full-Text
Keywords: dosimetry; Monte Carlo; SPECT; hybrid; CT; absorbed dose; therapy; reconstruction; quantitation; activity dosimetry; Monte Carlo; SPECT; hybrid; CT; absorbed dose; therapy; reconstruction; quantitation; activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Ljungberg, M.; Gleisner, K.S. Hybrid Imaging for Patient-Specific Dosimetry in Radionuclide Therapy. Diagnostics 2015, 5, 296-317.

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