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Diagnostics 2016, 6(3), 30; doi:10.3390/diagnostics6030030

18F-FET-PET in Primary Hyperparathyroidism: A Pilot Study

1
Department of Clinical Physiology and Nuclear Medicine, Gentofte Hospital, DK-2900 Hellerup, Denmark
2
Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, DK-2100 Copenhagen, Denmark
3
Department of Endocrinology, Herlev Hospital, DK-2730 Herlev, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Gary Cook
Received: 27 June 2016 / Revised: 9 August 2016 / Accepted: 11 August 2016 / Published: 17 August 2016
(This article belongs to the Collection Hybrid Imaging in Medicine)
View Full-Text   |   Download PDF [5653 KB, uploaded 17 August 2016]   |  

Abstract

Preoperative localisation of the diseased parathyroid gland(s) in primary hyperparathyroidism (PHP) is a prerequisite for subsequent minimally invasive surgery. Recently, as alternatives to conventional sestamibi parathyroid scintigraphy, the 11C-based positron emission tomography (PET) tracers methionine and choline have shown promise for this purpose. We evaluated the feasibility of using the 18F-based PET tracer fluoroethyl-l-tyrosine (FET), as the longer half-life of 18F makes it logistically more favourable. As a proof-of-concept study, we included two patients with PHP in which dual-isotope parathyroid subtraction single photon emission computed tomography had determined the exact location of the parathyroid adenoma. A dynamic FET PET/CT scan was performed with subsequent visual evaluation and calculation of target-to-background (TBR; parathyroid vs. thyroid). The maximum TBR in the two patients under study was achieved approximately 30 min after the injection of the tracer and was 1.5 and 1.7, respectively. This ratio was too small to allow for confident visualisation of the adenomas. FET PET/CT seems not feasible as a preoperative imaging modality in PHP. View Full-Text
Keywords: primary hyperparathyroidism; positron-emission tomography; (18F)fluoroethyl-l-tyrosine primary hyperparathyroidism; positron-emission tomography; (18F)fluoroethyl-l-tyrosine
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Krakauer, M.; Kjaer, A.; Bennedbæk, F.N. 18F-FET-PET in Primary Hyperparathyroidism: A Pilot Study. Diagnostics 2016, 6, 30.

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