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Diagnostics 2015, 5(3), 287-289; doi:10.3390/diagnostics5030287

In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous 18F-FDG-PET and Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect

1
Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark
2
Department of Veterinary Clinical and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C 2000, Denmark
3
Department of Electrical Engineering, Technical University of Denmark, Lyngby 2800, Denmark
4
GE Healthcare, Brøndby 2605, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Graham Jackson
Received: 13 May 2015 / Revised: 17 June 2015 / Accepted: 19 June 2015 / Published: 26 June 2015
(This article belongs to the Collection Hybrid Imaging in Medicine)
View Full-Text   |   Download PDF [677 KB, uploaded 26 June 2015]   |  

Abstract

In this communication the mismatch between simultaneous 18F-FDG-PET and a 13C-lactate imaging (hyperPET) in a biopsy verified squamous cell carcinoma in the right tonsil of a canine cancer patient is shown. The results demonstrate that 18F-FDG-PET may not always reflect the Warburg effect in all tumors. View Full-Text
Keywords: cancer; dynamic nuclear polarization; hyperpolarized; 13C-pyruvate; MR; 18F-FDG-PET; PET/MR; molecular imaging; hyperPET cancer; dynamic nuclear polarization; hyperpolarized; 13C-pyruvate; MR; 18F-FDG-PET; PET/MR; molecular imaging; hyperPET
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Gutte, H.; Hansen, A.E.; Larsen, M.M.; Rahbek, S.; Johannesen, H.H.; Ardenkjaer-Larsen, J.; Kristensen, A.T.; Højgaard, L.; Kjaer, A. In Vivo Phenotyping of Tumor Metabolism in a Canine Cancer Patient with Simultaneous 18F-FDG-PET and Hyperpolarized 13C-Pyruvate Magnetic Resonance Spectroscopic Imaging (hyperPET): Mismatch Demonstrates that FDG may not Always Reflect the Warburg Effect. Diagnostics 2015, 5, 287-289.

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