Special Issue "Epigenetics of Cancer Progression"
QuicklinksA special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (30 December 2010)
Special Issue Editors
Guest Editor
Prof. Dr. Jörg Haier
Comprehensive Cancer Center Muenster, International Patient Management, University Hospital Muenster, Waldeyerstr. 1, 48149 Muenster, Germany
Website: http://cccm.uni-muenster.de/
E-Mail:
Phone: +49 251 83 57630 (Labor 56326)
Fax: +49 251 83 57631
Interests: gastraintestinal cancer; metastasis; cell adhesion; cell migration; chemotaxis
Guest Editor
Dr. Soeren Torge Mees
Dept. of General and Visceral Surgery, University Hospital of Muenster, Waldeyerstr.1, 48149 Muenster, Germany
E-Mail:
Phone: +49 251 83 56301
Fax: +49 251 83 58424
Interests: pancreatic cancer; epigenetics; microRNAs; methylation; metastasis; animal models; hepato-pancreatico-biliary surgery
Published Papers
Special Issue Information
Dear Colleagues,
Epigenetic alterations seem to play an important role during the development and progression of several types of cancers. Of current interest are all epigenetic mechanisms, such as shifts in DNA methylation patterns or alterations in microRNA expression, that contribute to the the progression of cancer.
Prof. Dr. Jörg Haier
Dr. Soeren Torge Mees
Guest Editor
Submission
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 500 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
Keywords
- epigenetics
- microRNAs
- methylation
- metastasis
- tumor suppressor genes
- oncogenes
- animal models
Planned Papers
Title: Chromatin is the Battle - Field of Cancer Epigenetics
Authors: Lyudmyla P. Shvachko
Affiliation: The Institute of Molecular Biology & Genetics of NAS Ukraine; Department of Molecular Genetics, 03143, Kiev, #150 Zabolotnogo Str., Ukraine;
E-Mail: l.p.shvachko@imbg.org.ua
Abstract: An important feature of cancer development and progression is the change in DNA methylation patterns that directly connected with the chromatin alterations. Here, we focus our study on cancer-associated genomic DNA hypomethylation with a particular focus on global hypomethylation of the satellite DNA repeat sequences. The emerging data provide insights into the importance of methylation of repeated DNA sequences in the maintenance of chromatine and chromosome structural integrity. We have studied that cancer-binding DNA hypomethylation is a basic player on the chromatin battle-field in cancer epigenetics. We shown that dramatically the loss of genomic DNA methylation in cancer contributes in global DNA hypomethylation of major pericentromeric/centromeric Alu repeats. We have suggested the dual function of the methylated Alu repeats in chromatin formation. There are methylated Alu repeats as the epigenetic loci for the non-histone chromatin methyl-binding proteins from one side, and methylated DNA repeats as Alu might be the epigenetic sites for the linker histone H1 on the other hand. Taken together we resumed that disruption of both these epigenetic functions of pericentromeric/centromeric satellite DNA repeats during global hypomethylation resulted in crucial chromatin decompactisation in cancerogenesis. We consider the chromatin decompactization event caused by cancer-associated DNA hypomethylation with the potential for the use in diagnosis, prognosis and progression of cancers.
Last update: 12 May 2011