Special Issue "Organ-Specific Metastasis Formation"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (30 November 2010)
Prof. Dr. Jörg Haier
Comprehensive Cancer Center Muenster, International Patient Management, University Hospital Muenster, Waldeyerstr. 1, 48149 Muenster, Germany
Phone: +49 251 83 57630
Fax: +49 251 83 57631
Interests: gastraintestinal cancer; metastasis; cell adhesion; cell migration; chemotaxis
Dr. Peter Gassmann
Department of General and Abdominal Surgery, University Medicine of the Johannes Gutenberg-University Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany
Phone: +49 (0)251 83-56301
Fax: +49 (0)251 83-56480
Interests: gastrointestinal cancers; mechanisms of metastasis formation; tumor cell adhesion and migration; animal models; gastro-intestinal surgery; hepato-biliary surgery
The development of secondary distant organ and lymph node metastasis has an extraordinary impact on the prognosis of patients with solid cancer. In most cases the advent of metastatic growth represents the turning point from a local, potentially curable, disease to a systemic non-curable situation. As a highly regulated process, metastasis formation follows a distinct, non-random pattern characteristic for each tumor entity.
Metastasis formation and strategies to prevent this lethal event in the progression of cancer is of fundamental interest for cancer science and patient care. For this special issue of 'Cancers', papers high-lightning cellular mechanisms of metastasis formation, genetic and epigenetic aspects associated with organ and tumor specific metastasis formation, as well as papers outlining experimental and clinical therapeutic concepts for anti-metastatic treatment are welcome. We especially encourage the submission of papers presenting innovative animal models of organ specific metastasis formation.
Dr. Peter Gassmann
- organ specific metastasis
- animal models
- anti-metastatic treatment
- metastasis (-suppressor) genes
- lymph nod metastasis