Cancers 2011, 3(2), 1672-1690; doi:10.3390/cancers3021672
Article

Role of Gene Methylation in Antitumor Immune Response: Implication for Tumor Progression

1, 1 and 2,* email
Received: 22 December 2010; in revised form: 9 March 2011 / Accepted: 24 March 2011 / Published: 29 March 2011
(This article belongs to the Special Issue Epigenetics of Cancer Progression)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Cancer immunosurveillance theory has emphasized the role of escape mechanisms in tumor growth. In this respect, a very important factor is the molecular characterization of the mechanisms by which tumor cells evade immune recognition and destruction. Among the many escape mechanisms identified, alterations in classical and non-classical HLA (Human Leucocyte Antigens) class I and class II expression by tumor cells are of particular interest. In addition to the importance of HLA molecules, tumor-associated antigens and accessory/co-stimulatory molecules are also involved in immune recognition. The loss of HLA class I antigen expression and of co-stimulatory molecules can occur at genetic, transcriptional and post-transcriptional levels. Epigenetic defects are involved in at least some mechanisms that preclude mounting a successful host-antitumor response involving the HLA system, tumor-associated antigens, and accessory/co-stimulatory molecules. This review summarizes our current understanding of the role of methylation in the regulation of molecules involved in the tumor immune response.
Keywords: methylation; tumor; HLA; clusterin
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MDPI and ACS Style

Serrano, A.; Castro-Vega, I.; Redondo, M. Role of Gene Methylation in Antitumor Immune Response: Implication for Tumor Progression. Cancers 2011, 3, 1672-1690.

AMA Style

Serrano A, Castro-Vega I, Redondo M. Role of Gene Methylation in Antitumor Immune Response: Implication for Tumor Progression. Cancers. 2011; 3(2):1672-1690.

Chicago/Turabian Style

Serrano, Alfonso; Castro-Vega, Isabel; Redondo, Maximino. 2011. "Role of Gene Methylation in Antitumor Immune Response: Implication for Tumor Progression." Cancers 3, no. 2: 1672-1690.

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