Special Issue "Exploring Inflammation in Cancers"
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: closed (30 May 2011)
Prof. Dr. Masanobu Oshima
Division of Genetics, Cancer Research Institute, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
Interests: cancer genetics; molecular pathology of gastrointestinal cancers; cancer stem cell and Wnt signaling
Epidemiological studies have shown that regular use of non-steroidal anti-inflammatory drugs (NSAIDs) is associated with a reduced risk of cancer development. NSAIDs exert their anti-inflammatory activity through the inhibition of cyclooxygenase-2 (COX-2), resulting in suppression of prostaglandin E2 (PGE2) biosynthesis. Consistently, genetic studies using mouse models have demonstrated that a proinflammatory prostaglandin PGE2 plays an essential role in gastrointestinal cancer development through induction of angiogenesis or suppression of tumor immunity. On the other hand, NF-kB and Stat3 are two major transcription factors in the inflammatory response, which are activated by TNF-a and IL-6, respectively. It has been shown that activation of both NF-kB and Stat3 is required for colitis-associated cancer development in mouse models through inhibition of apoptosis and acceleration of cell proliferation. These results, taken together, indicate that inflammatory signaling networks promote tumor development through multiple pathways. Moreover, recent studies have also indicated that inflammation causes tumor initiation by induction of epigenetic or genetic alterations, and malignant progression through remodeling the metastatic microenvironment. Accordingly, it is possible that targeting inflammation is an effective therapeutic strategy against cancer initiation, promotion and progression. This special issue on “Exploring Inflammation in Cancers” will include original research articles and review papers in the field of inflammation and cancer, including, but not limited to, infection-associated cancer (H. pylori, HCV etc.), cytokine/chemokine signaling in cancer development, innate immunity and acquired immunity (Th1, Th2 or Th17) in cancer development, tumor-associated macrophages (TAMs) in tumorigenesis, and inflammation and epigenetics. Thank you for your collaboration.
Prof. Dr. Masanobu Oshima
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 500 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- NF-kappa B
- tumor-associated macrophages
- colitis-associated cancer
- innate immunity
Article: Acquisition of Genetic Aberrations by Activation-Induced Cytidine Deaminase (AID) during Inflammation-Associated Carcinogenesis
Cancers 2011, 3(2), 2750-2766; doi:10.3390/cancers3022750
Received: 13 May 2011; in revised form: 9 June 2011 / Accepted: 14 June 2011 / Published: 22 June 2011| Download PDF Full-text (297 KB) | Download XML Full-text
Cancers 2011, 3(3), 2811-2826; doi:10.3390/cancers3032811
Received: 23 May 2011; in revised form: 17 June 2011 / Accepted: 21 June 2011 / Published: 27 June 2011| Download PDF Full-text (512 KB) | Download XML Full-text
Cancers 2011, 3(3), 3018-3028; doi:10.3390/cancers3033018
Received: 3 June 2011; in revised form: 12 July 2011 / Accepted: 19 July 2011 / Published: 25 July 2011| Download PDF Full-text (1164 KB) | Download XML Full-text
Review: Toll-Like Receptor 4 Signaling Integrates Intestinal Inflammation with Tumorigenesis: Lessons from the Murine Model of Colitis-Associated Cancer
Cancers 2011, 3(3), 3104-3113; doi:10.3390/cancers3033104
Received: 9 June 2011; in revised form: 25 July 2011 / Accepted: 26 July 2011 / Published: 2 August 2011| Download PDF Full-text (832 KB) | Download XML Full-text
Cancers 2011, 3(3), 3156-3168; doi:10.3390/cancers3033156
Received: 10 June 2011; in revised form: 2 August 2011 / Accepted: 4 August 2011 / Published: 8 August 2011| Download PDF Full-text (390 KB) | Download XML Full-text
Cancers 2011, 3(3), 3189-3205; doi:10.3390/cancers3033189
Received: 4 July 2011; in revised form: 28 July 2011 / Accepted: 4 August 2011 / Published: 9 August 2011| Download PDF Full-text (670 KB) | Download XML Full-text
Review: Inflammation-Related Carcinogenesis and Prevention in Esophageal Adenocarcinoma Using Rat Duodenoesophageal Reflux Models
Cancers 2011, 3(3), 3206-3224; doi:10.3390/cancers3033206
Received: 17 May 2011; in revised form: 2 August 2011 / Accepted: 4 August 2011 / Published: 10 August 2011| Download PDF Full-text (890 KB) | Download XML Full-text
Article: Infiltration of M2 Tumor-Associated Macrophages in Oral Squamous Cell Carcinoma Correlates with Tumor Malignancy
Cancers 2011, 3(4), 3726-3739; doi:10.3390/cancers3043726
Received: 13 September 2011; in revised form: 20 September 2011 / Accepted: 22 September 2011 / Published: 28 September 2011| Download PDF Full-text (1757 KB) | Download XML Full-text
Cancers 2011, 3(4), 3740-3761; doi:10.3390/cancers3043740
Received: 31 August 2011; in revised form: 15 September 2011 / Accepted: 19 September 2011 / Published: 28 September 2011| Download PDF Full-text (1493 KB) | Download XML Full-text
Cancers 2011, 3(4), 3894-3908; doi:10.3390/cancers3043894
Received: 13 September 2011; in revised form: 7 October 2011 / Accepted: 9 October 2011 / Published: 14 October 2011| Download PDF Full-text (231 KB) | Download XML Full-text
Last update: 25 September 2012