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Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis
Lab of Translational Medicine, Lee Gil Ya Cancer and Diabetes Institute, Gachon University of Medicine and Science, 7-45 Songdo-dong, Yeonsu-gu, Incheon 406-840, Korea
Department of Gastroenterology, Gachon Graduate School of Medicine, Gil Hospital, Incheon 406-840, Korea
* Author to whom correspondence should be addressed.
Received: 3 June 2011; in revised form: 12 July 2011 / Accepted: 19 July 2011 / Published: 25 July 2011
Abstract: Epidemiological and experimental evidence has emerged that a dysregulated inflammation is associated with most of the tumors, and many studies have begun to unravel the molecular pathways linking inflammation and cancer. As a typical example linking these associations, Helicobacter pylori (H. pylori) infection-associated atrophic gastritis has been recognized as precursor lesion of gastric cancer. The identification of transcription factors such as NF-κB and STAT3, and their gene products such as IL-8, COX-2, iNOS, cytokines, chemokines and their receptors, etc have laid the molecular foundation for our understanding of the decisive role of inflammation in carcinogenesis. In addition to the role as the initiator of cancer, inflammation contributes to survival and proliferation of malignant cells, tumor angiogenesis, and even metastasis. In this review, the fundamental mechanisms of H. pylori-induced carcinogenesis as well as the possibility of cancer prevention through suppressing H. pylori-induced inflammation are introduced. We infer that targeting inflammatory pathways have a potential role to detour the unpleasant journey to H. pylori-associated gastric carcinogenesis.
Keywords: gastric cancer; inflammation; Helicobacter pylori; cancer prevention
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Kim, E.-H.; Hong, K.-S.; Hong, H.; Hahm, K.B. Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis. Cancers 2011, 3, 3018-3028.
Kim E-H, Hong K-S, Hong H, Hahm KB. Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis. Cancers. 2011; 3(3):3018-3028.
Kim, Eun-Hee; Hong, Kyung-Sook; Hong, Hua; Hahm, Ki Baik. 2011. "Detouring the Undesired Route of Helicobacter pylori-Induced Gastric Carcinogenesis." Cancers 3, no. 3: 3018-3028.