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Cancers 2011, 3(4), 3894-3908; doi:10.3390/cancers3043894

The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer

1 Departments of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA 2 Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030, USA
* Author to whom correspondence should be addressed.
Received: 13 September 2011 / Revised: 7 October 2011 / Accepted: 9 October 2011 / Published: 14 October 2011
(This article belongs to the Special Issue Exploring Inflammation in Cancers)
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Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the USA. Colorectal cancer progression and metastasis depends on the orchestration of the aberrant signaling pathways that control tumor cell proliferation, survival and migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF) signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In this review, we highlight major advances in our understanding of the roles of PTGS2 and EGF signaling in colorectal cancer.
Keywords: PTGS2; COX-2; EGFR; colorectal cancer PTGS2; COX-2; EGFR; colorectal cancer
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wang, D.; Xia, D.; DuBois, R.N. The Crosstalk of PTGS2 and EGF Signaling Pathways in Colorectal Cancer. Cancers 2011, 3, 3894-3908.

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