Special Issue "Sphingolipids and Bioactive Lipids"
A special issue of Biomolecules (ISSN 2218-273X).
Deadline for manuscript submissions: closed (31 May 2013)
Prof. Dr. Yusuf A. Hannun
Director of Stony Brook Cancer Center, Vice Dean for Cancer Medicine, Joel Kenny Professor of Medicine, Stony Brook University, Health Science Center, Stony Brook, NY 11794, USA
Phone: +1 631 444 8067
Fax: +1 631 444 2661
Interests: bioactive lipids; ceramide; sphingolipids; sphingomyelinases; protein kinase C; protein phosphatases
Dr. Cungui Mao
Lipid Cancer Lab, Department of Medicine. SUNY at Stony Brook, Mail Code 8155, Stony Brook, NY 11794-8155, USA
Dr. Chiara Luberto
Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794, USA
It has been approximately one hundred and thirty years since the identification of the first sphingolipid, and the progress in understanding the roles and functions of this enigmatic class of lipids has since been remarkable. With this scientific progress came the unanticipated realization of the great complexity of sphingolipid metabolism with current estimates of several thousand individual sphingolipid molecular species. Many of these compounds are now recognized as bioactive molecules, often with opposing roles, such as ceramide and sphingosine 1-phosphate, and their specific roles in regulation of many fundamental cellular processes, such as cell proliferation, differentiation and cell death is now widely documented. Thus, it comes as no surprise that altered regulation of sphingolipid metabolism has been found to contribute to the development and/or maintenance of pathological conditions, such as cancer, neurodegenerative diseases, diabetes and metabolic regulation, and infections and immunity. This explosion in research has necessitated a more focused approach on specific pathways and specific pathobiologies. Thus, the aim of this special issue is to focus on the roles and functions of the various sphingolipids in the development, progression and treatment of various cancers. Still, we have only scratched the surface. With these considerations in mind, we invite the submission of research and review articles that address the proposed topic by covering basic as well as clinical aspects of sphingolipids or sphingolipid-metabolizing enzymes in the context of the various cancers. We also encourage the submission of articles documenting the use of innovative techniques/approaches for quantitative analysis, imaging and in vivo modulation of sphingolipids that could exert a significant impact in the general understanding of the exciting topic.
We look forward to reading your contributions.
Prof. Dr. Yusuf Hannun
Dr. Cungui Mao
Dr. Chiara Luberto
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 300 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- ER stress
- cell adhesion
- cell migration
- sphingosine-1-phosphate (S1P)
- lipid signaling
- cell proliferation
- cell differentiation
- cancer metabolism
- cancer energetics
- cancer animal models
- cancer therapeutics
Biomolecules 2013, 3(2), 303-315; doi:10.3390/biom3020303
Received: 19 April 2013; in revised form: 3 May 2013 / Accepted: 6 May 2013 / Published: 14 May 2013| Download PDF Full-text (385 KB) | Download XML Full-text
Article: The Roles of Sphingosine Kinase 1 and 2 in Regulating the Metabolome and Survival of Prostate Cancer Cells
Biomolecules 2013, 3(2), 316-333; doi:10.3390/biom3020316
Received: 9 May 2013; in revised form: 3 June 2013 / Accepted: 4 June 2013 / Published: 10 June 2013| Download PDF Full-text (343 KB) | Download XML Full-text
Article: Sphingosine Phosphate Lyase Regulates Murine Embryonic Stem Cell Proliferation and Pluripotency through an S1P2/STAT3 Signaling Pathway
Biomolecules 2013, 3(3), 351-368; doi:10.3390/biom3030351
Received: 18 April 2013; in revised form: 15 June 2013 / Accepted: 20 June 2013 / Published: 24 June 2013| Download PDF Full-text (503 KB) | Download XML Full-text
Article: Regulation of Cytoskeleton Organization by Sphingosine in a Mouse Cell Model of Progressive Ovarian Cancer
Biomolecules 2013, 3(3), 386-407; doi:10.3390/biom3030386
Received: 3 June 2013; in revised form: 4 July 2013 / Accepted: 8 July 2013 / Published: 16 July 2013| Download PDF Full-text (1353 KB) | Download XML Full-text
Biomolecules 2013, 3(3), 408-434; doi:10.3390/biom3030408
Received: 11 June 2013; in revised form: 4 July 2013 / Accepted: 8 July 2013 / Published: 23 July 2013| Download PDF Full-text (560 KB) | Download XML Full-text
Biomolecules 2013, 3(3), 435-448; doi:10.3390/biom3030435
Received: 23 May 2013; in revised form: 10 July 2013 / Accepted: 24 July 2013 / Published: 25 July 2013| Download PDF Full-text (520 KB) | Download XML Full-text
Biomolecules 2013, 3(3), 481-513; doi:10.3390/biom3030481
Received: 1 July 2013; in revised form: 2 August 2013 / Accepted: 3 August 2013 / Published: 12 August 2013| Download PDF Full-text (1033 KB)
Last update: 8 April 2013