Special Issue "Sphingolipids and Bioactive Lipids"

Guest Editor
Prof. Dr. Yusuf A. Hannun
Director of Stony Brook Cancer Center, Vice Dean for Cancer Medicine, Joel Kenny Professor of Medicine, Stony Brook University, Health Science Center, Stony Brook, NY 11794, USA
Website: http://academicdepartments.musc.edu/musc/news/res_news/archive/Feb09_16hannun.htm
E-Mail: yusuf.hannun@sbumed.org
Phone: +1 631 444 8067
Fax: +1 631 444 2661
Interests: bioactive lipids; ceramide; sphingolipids; sphingomyelinases; protein kinase C; protein phosphatases

Guest Editor
Dr. Cungui Mao
Lipid Cancer Lab, Department of Medicine. SUNY at Stony Brook, Mail Code 8155, Stony Brook, NY 11794-8155, USA
E-Mail: Cungui.Mao@stonybrookmedicine.edu

Guest Editor
Dr. Chiara Luberto
Department of Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794, USA
E-Mail: chiara.luberto@stonybrook.edu

Dear Colleagues,

It has been approximately one hundred and thirty years since the identification of the first sphingolipid, and the progress in understanding the roles and functions of this enigmatic class of lipids has since been remarkable. With this scientific progress came the unanticipated realization of the great complexity of sphingolipid metabolism with current estimates of  several thousand individual sphingolipid molecular species. Many of these compounds are now recognized as bioactive molecules, often with opposing roles, such as ceramide and sphingosine 1-phosphate, and their specific roles in regulation of many fundamental cellular processes, such as cell proliferation, differentiation and cell death is now widely documented. Thus, it comes as no surprise that altered regulation of sphingolipid metabolism has been found to contribute to the development and/or maintenance of pathological conditions, such as cancer, neurodegenerative diseases, diabetes and metabolic regulation, and infections and immunity. This explosion in research has necessitated a more focused approach on specific pathways and specific pathobiologies. Thus, the aim of this special issue is to focus on the roles and functions of the various sphingolipids in the development, progression and treatment of various cancers. Still, we have only scratched the surface. With these considerations in mind, we invite the submission of research and review articles that address the proposed topic by covering basic as well as clinical aspects of sphingolipids or sphingolipid-metabolizing enzymes in the context of the various cancers. We also encourage the submission of articles documenting the use of innovative techniques/approaches for quantitative analysis, imaging and in vivo modulation of sphingolipids that could exert a significant impact in the general understanding of the exciting topic.

We look forward to reading your contributions.

Prof. Dr. Yusuf Hannun
Dr. Cungui Mao
Dr. Chiara Luberto
Guest Editors

Submission

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• autophagy
• ER stress
• cell adhesion
• cell migration
• metastasis
• inflammation
• ceramide
• sphingosine
• sphingosine-1-phosphate (S1P)
• lipid signaling
• cell proliferation
• cell differentiation
• apoptosis
• cancer metabolism
• cancer energetics
• angiogenesis
• oncogenes
• cancer animal models
• cancer therapeutics
• lipidomics