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Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis
Division of Surgical Oncology, Department of Surgery, Virginia Commonwealth University School of Medicine and Massey Cancer Center, Richmond, VA 23298-0011, USA
* Author to whom correspondence should be addressed.
Received: 11 June 2013; in revised form: 4 July 2013 / Accepted: 8 July 2013 / Published: 23 July 2013
Abstract: The main function of the lymphatic system is to control and maintain fluid homeostasis, lipid transport, and immune cell trafficking. In recent years, the pathological roles of lymphangiogenesis, the generation of new lymphatic vessels from preexisting ones, in inflammatory diseases and cancer progression are beginning to be elucidated. Sphingosine-1-phosphate (S1P), a bioactive lipid, mediates multiple cellular events, such as cell proliferation, differentiation, and trafficking, and is now known as an important mediator of inflammation and cancer. In this review, we will discuss recent findings showing the emerging role of S1P in lymphangiogenesis, in inflammation, and in cancer.
Keywords: sphingolipids; sphingosine-1-phosphate; inflammation; lymphangiogenesis; cancer; lymphatic endothelial cell; VEGF; angiopoietin; spinster 2; metastasis
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Cite This Article
MDPI and ACS Style
Huang, W.-C.; Nagahashi, M.; Terracina, K.P.; Takabe, K. Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis. Biomolecules 2013, 3, 408-434.
Huang W-C, Nagahashi M, Terracina KP, Takabe K. Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis. Biomolecules. 2013; 3(3):408-434.
Huang, Wei-Ching; Nagahashi, Masayuki; Terracina, Krista P.; Takabe, Kazuaki. 2013. "Emerging Role of Sphingosine-1-phosphate in Inflammation, Cancer, and Lymphangiogenesis." Biomolecules 3, no. 3: 408-434.