Special Issue "Intrinsically Disordered Proteins and Chronic Diseases"

A special issue of Biomolecules (ISSN 2218-273X).

Deadline for manuscript submissions: 1 December 2018

Special Issue Editors

Guest Editor
Dr. Prakash Kulkarni

City of Hope National Medical Center, Duarte, CA, USA
Website | E-Mail
Interests: IDP conformational dynamics; phenotypic switching, non-genetic mechanisms in phenotypic heterogeneity; bet-hedging in evolution
Guest Editor
Assoc. Prof. Dr. Vladimir N. Uversky

Molecular Medicine, University of South Florida, Tampa, USA
Website | E-Mail
Interests: intrinsically disordered proteins; protein folding; protein misfolding; partially folded proteins; protein aggregation; protein structure; protein function; protein biophysics; protein bioinformatics; conformational diseases; protein–ligand interactions; protein–protein interactions

Special Issue Information

Dear Colleagues,

It is now increasingly evident that a large fraction of the human proteome comprises proteins, or regions within proteins that lack a 3D structure under physiological conditions, and are referred to as intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs), respectively. Despite their lack of a stable structure, IDPs/IDPRs are involved in regulation, signaling, and control, where binding to multiple partners and high-specificity/low-affinity interactions plays a crucial role. Furthermore, intrinsic disorder is a unique structural feature that enables IDPs/IDPRs to participate in, both, one-to-many and many-to-one signaling. Since they serve as general regulators of various cellular processes, IDPs/IDPRs themselves are tightly controlled. However, when overexpressed, miss-expressed, or dysregulated, IDPs/IDPRs are prone to engage in promiscuous, often unwanted interactions and, thus, may lead to the development of various pathological states.

This Special Issue of Biomolecules is dedicated to exploring the role of IDPs in various chronic diseases. The main goal is to compile articles that describe recent progress in elucidating the mechanisms by which IDPs cause variious human diseases, such as cancer, cardiovascular disease, amyloidoses, neurodegenerative diseases, diabetes, genetic diseases, to name just a few.

Prakash Kulkarni
Vladimir N. Uversky
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 650 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Intrinsically Disordered Protein
  • Cancer
  • Diabetes
  • Neurodegenerative diseases
  • Amyloidoses
  • Cardiovascular diseases
  • Genetic diseases
  • Protein structure
  • Protein function

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

1) Mark E. Bowen, Hugo Sanabria, Tatyana Smirnova, Keith R. Weninger. Spontaneous switching between conformational ensembles in intrinsically disordered proteins.

2) Prakash Kulkarni, Mohit Jolly, Xingcheng Lin, Federico, Yanan He, Yihong Chen, Krithika Rajagopalan, Steven M. Mooney, Yu Zeng, Keith Weninger, Alex Grishaev, Jose Onuchic, Herbert Levine, Ravi Salgia, Vladimir Uversky, John Orban. Conformational dynamics of PAGE4 and phenotypic switching in prostate cancer.

3) Nagarajan Vaidehi and Supriyo Bhattacharya. Emerging multiscale computational methods for understanding the structure and function of intrinsically disordered proteins.

4) E. Brad Thompson and Raj Kumar. Role of phosphorylation in the modulation of glucocorticoid receptor’s intrinsically disordered domain.

5) Christophe Bignon, Francesca Troilo, Stefano Gianni and Sonia Longhi. Modulation of NTAIL interactions through fuzziness and sequence features of disordered binding sites.

6) Oxana V. Galzitskaya et al. Search for functions of intrinsically disordered prion-like domains for FET proteins involved in amyotrophic lateral sclerosis and frontotemporal dementia.

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