Table of Contents
Pharmaceutics, Volume 9, Issue 1 (March 2017)
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Cover Story (view full-size image) Doxorubicin was effectively delivered by pH and redox dual responsive hollow nanocapsules which [...] Read more. Doxorubicin was effectively delivered by pH and redox dual responsive hollow nanocapsules which were prepared by stabilizing polyamidoamine dendron-poly(L-lysine) (PAMAM dendron-PLL) vesicles through the introduction of disulfide bonds between PLLs. PAMAM dendron, cross-linked PLL membrane and disulfide bond in the nanocapsules can provide a buffering effect for endosomal escape, an electrostatic barrier for doxorubicin entrapment and redox-responsive release by destabilizing nanocapsules, respectively. Eventually, the doxorubicin delivered into the cytoplasm could exhibit an effective anticancer effect on HeLa cells. View the paper.