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Pharmaceutics 2017, 9(1), 2; doi:10.3390/pharmaceutics9010002

Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates

1
Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa
2
Department of Chemical and Metallurgical Engineering, Tshwane University of Technology, Pretoria 0001, South Africa
*
Author to whom correspondence should be addressed.
Academic Editor: Murali Mohan Yallapu
Received: 21 October 2016 / Revised: 24 November 2016 / Accepted: 30 November 2016 / Published: 26 December 2016
(This article belongs to the Special Issue Nanotechnology in Medical Therapeutic Formulations)
View Full-Text   |   Download PDF [1556 KB, uploaded 26 December 2016]   |  

Abstract

Bisphosphonates have found application in the treatment of reoccurrence of bone diseases, breast cancer, etc. They have also been found to exhibit antimicrobial, anticancer and antimalarial activities. However, they suffer from pharmacological deficiencies such as toxicity, poor bioavailability and low intestinal adsorption. These shortcomings have resulted in several researchers developing delivery systems that can enhance their overall therapeutic effectiveness. This review provides a detailed overview of the published studies on delivery systems designed for the delivery of bisphosphonates and the corresponding in vitro/in vivo results. View Full-Text
Keywords: bisphosphonates; drug delivery systems; biomaterials; nanocapsules bisphosphonates; drug delivery systems; biomaterials; nanocapsules
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Aderibigbe, B.; Aderibigbe, I.; Popoola, P. Design and Biological Evaluation of Delivery Systems Containing Bisphosphonates. Pharmaceutics 2017, 9, 2.

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