Table of Contents
Int. J. Mol. Sci., Volume 18, Issue 11 (November 2017)
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Cover Story (view full-size image) Nitric oxide (NO) and its downstream cGMP-activated pathway have been established as important [...] Read more. Nitric oxide (NO) and its downstream cGMP-activated pathway have been established as important elements in maintaining high-fidelity synaptic transmission under strong stimulation. NO generated post-synaptically by a neuronal NO synthase (nNOS) can diffuse to the presynaptic terminal triggering the synthesis of cGMP by the soluble guanylyl cyclase (sGC). Then, cGMP activates the cGMP-dependent protein kinases (cGKs) that regulate the synaptic vesicle exoendocytic cycle and transmitter release. View this paper