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Int. J. Mol. Sci. 2017, 18(11), 2479; https://doi.org/10.3390/ijms18112479

Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase

1
Faculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan
2
Pharmaceutical Research and Technology Institute, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan
*
Authors to whom correspondence should be addressed.
Received: 18 October 2017 / Revised: 13 November 2017 / Accepted: 16 November 2017 / Published: 21 November 2017
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Abstract

Two new ergostane-type sterols; (22E)-5α,6α-epoxyergosta-8,14,22-triene-3β,7β-diol (1) and 5α,6α-epoxyergost-8(14)-ene-3β,7α-diol (2) were isolated from the fruiting bodies of king trumpet mushroom (Pleurotus eryngii), along with eight known compounds (310). All isolated compounds were evaluated for their inhibitory effects on aromatase. Among them, 4 and 6 exhibited comparable aromatase inhibitory activities to aminoglutethimide. View Full-Text
Keywords: Pleurotus eryngii; sterol; ergostane; aromatase inhibitor Pleurotus eryngii; sterol; ergostane; aromatase inhibitor
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Kikuchi, T.; Motoyashiki, N.; Yamada, T.; Shibatani, K.; Ninomiya, K.; Morikawa, T.; Tanaka, R. Ergostane-Type Sterols from King Trumpet Mushroom (Pleurotus eryngii) and Their Inhibitory Effects on Aromatase. Int. J. Mol. Sci. 2017, 18, 2479.

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