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Int. J. Mol. Sci. 2017, 18(11), 2475; https://doi.org/10.3390/ijms18112475

Effect of Different Skin Penetration Promoters in Halobetasol Propionate Permeation and Retention in Human Skin

1
Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
2
Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Received: 29 October 2017 / Revised: 14 November 2017 / Accepted: 17 November 2017 / Published: 21 November 2017
(This article belongs to the Special Issue Inflammatory Skin Conditions 2017)
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Abstract

Halobetasol propionate (HB) is a potent synthetic corticosteroid used against inflammatory skin diseases, such as dermatitis, eczema, and psoriasis, among others. The aim of this study is to define how the presence of different skin penetration enhancers (nonane, menthone, limonene, azone, carene, decanol, linoleic acid and cetiol) affects the penetration and retention in skin of HB. To determine drug penetration through skin, 5% of each promoter was used in an ex vivo system with human skin on Franz cells. The results showed that the highest permeation occurs in the presence of menthone, followed by nonane. Permeation parameters were determined. The in vivo test was assessed, and the formulation containing HB-menthone presented better anti-inflammatory efficacy. These results are useful to generate a specific treatment according to each patient’s needs, and the inflammatory characteristics of the disease. View Full-Text
Keywords: halobetasol propionate; permeation enhancers; skin permeation; skin inflammation; topical corticosteroid halobetasol propionate; permeation enhancers; skin permeation; skin inflammation; topical corticosteroid
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Carvajal-Vidal, P.; Mallandrich, M.; García, M.L.; Calpena, A.C. Effect of Different Skin Penetration Promoters in Halobetasol Propionate Permeation and Retention in Human Skin. Int. J. Mol. Sci. 2017, 18, 2475.

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