Next Issue
Previous Issue

E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Table of Contents

Molecules, Volume 5, Issue 5 (May 2000), Pages 701-755

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
  • You may sign up for e-mail alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Readerexternal link to open them.
View options order results:
result details:
Displaying articles 1-8
Export citation of selected articles as:

Research

Jump to: Other

Open AccessArticle Utility of Sulphones in Heterocyclic Synthesis: Synthesis of Some Pyridine, Chromene and Thiophene Derivatives
Molecules 2000, 5(5), 701-709; doi:10.3390/50500701
Received: 3 August 1999 / Revised: 13 October 1999 / Accepted: 13 October 1999 / Published: 5 May 2000
Cited by 16 | PDF Full-text (42 KB)
Abstract Phenylsulfonylacetonitrile (1) when reacted with α,β-unsaturated nitriles (2a,b) and/or 2-hydroxynaphthaldehyde yields pyridine derivatives (3a,b) and / or the iminochromene derivative (4) respectively. The behavior of (1) towards some a-halogenated compounds has been investigated. Full article
Open AccessArticle Synthesis of N,N’-Diarylalkanediamides and Their Antimycobacterial and Antialgal Activity
Molecules 2000, 5(5), 714-726; doi:10.3390/50500714
Received: 2 November 1999 / Accepted: 13 December 1999 / Published: 14 May 2000
Cited by 7 | PDF Full-text (42 KB)
Abstract
A set of N,N'-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N'-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacterially active substances were found only in the series of N,N'-diarylethanediamides and N,N'-diarylbutanediamides. [...] Read more.
A set of N,N'-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N'-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacterially active substances were found only in the series of N,N'-diarylethanediamides and N,N'-diarylbutanediamides. Other compounds (derivatives of pentane-, hexane-, octane- and nonanediamide) were inactive against various strains of mycobacteria. The compounds inhibited growth and chlorophyll production in Chlorella vulgaris. Their relatively low antialgal activity is probably connected with their lowered aqueous solubility, and hence by a restricted passage of the inhibitor through the hydrophilic regions of thylakoid membranes. Full article
Open AccessArticle Synthesis of 2’-Modified Nucleotides
Molecules 2000, 5(5), 727-729; doi:10.3390/50500727
Received: 4 May 2000 / Accepted: 10 May 2000 / Published: 15 May 2000
PDF Full-text (17 KB)
Abstract
We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic [...] Read more.
We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with potential application in gene therapy. Full article
Open AccessArticle Synthesis and Characterization of New Surface Active Azo Initiators for Radical Reactions
Molecules 2000, 5(5), 730-736; doi:10.3390/50500730
Received: 10 January 2000 / Accepted: 10 May 2000 / Published: 18 April 2000
Cited by 9 | PDF Full-text (38 KB)
Abstract
The synthesis of a water soluble azo initiators from 2,2’-azodiisobutyronitrile (AIBN) was performed in three steps: reaction of dinitrile with aromatic alcohols in the presence of HCl to form bisiminoesters hydrochlorides which are hydrolyzed to the esters and final regioselective sulfonation of [...] Read more.
The synthesis of a water soluble azo initiators from 2,2’-azodiisobutyronitrile (AIBN) was performed in three steps: reaction of dinitrile with aromatic alcohols in the presence of HCl to form bisiminoesters hydrochlorides which are hydrolyzed to the esters and final regioselective sulfonation of the aromatic esters. The thermal decomposition of the azo initiators obtained leads to formation of two surface active radicals which can start the chain reaction. Full article
Open AccessArticle Structural Elucidation of Z- and E- Isomers of 5-Alkyl-4-ethoxycarbonyl-5-(4`-chlorophenyl)-3-oxa-4-pentenoic Acids
Molecules 2000, 5(5), 737-745; doi:10.3390/50500737
Received: 6 September 1999 / Revised: 7 November 1999 / Accepted: 7 February 2000 / Published: 20 May 2000
Cited by 2 | PDF Full-text (35 KB)
Abstract
Z- and E-isomers of 5-alkyl-4-ethoxycarbonyl-5-(4`-chlorophenyl)-3-oxa-4-pentenoic acids were prepared via the condensation of p-chloroacetophenone and/or pchloropropiophenone with diethyl-2,2`-oxydiacetate in the presence of sodium hydride as a basic catalyst. The Z-isomers of 2a and 2b were found to be predominant. The behaviour of the [...] Read more.
Z- and E-isomers of 5-alkyl-4-ethoxycarbonyl-5-(4`-chlorophenyl)-3-oxa-4-pentenoic acids were prepared via the condensation of p-chloroacetophenone and/or pchloropropiophenone with diethyl-2,2`-oxydiacetate in the presence of sodium hydride as a basic catalyst. The Z-isomers of 2a and 2b were found to be predominant. The behaviour of the corresponding anhydrides towards the action of hydrazine, phenylhydrazine, primary aromatic amines, hydrocarbons and ethanolysis has also been investigated. The structures and configurations of the products have been elucidated by chemical and spectroscopic means. Full article
Open AccessArticle Behaviour of Some Activated Nitriles Toward Barbituric Acid, Thiobarbituric Acid and 3-Methyl-1-Phenylpyrazol-5-one
Molecules 2000, 5(5), 746-755; doi:10.3390/50500746
Received: 6 September 1999 / Revised: 15 December 1999 / Accepted: 12 February 2000 / Published: 20 May 2000
Cited by 7 | PDF Full-text (262 KB)
Abstract The effect of some active methylene containing heterocyclic compounds, namely barbituric acid, thiobarbituric acid and 3-methyl-1-phenylpyrazol-5-one on a-cyano-3,4,5-trimethoxycinnamonitrile and ethyl a-cyano-3,4,5-trimethoxycinnamate (1a,b) was investigated. The structure of the new products was substantiated by their IR,1H-NMR and mass spectra. Full article

Other

Jump to: Research

Open AccessBook Review The Age of the Molecule. Edited by Nina Hall
Molecules 2000, 5(5), 710-711; doi:10.3390/50500710
Received: 18 March 2000 / Published: 23 April 2000
PDF Full-text (5 KB)
Open AccessBook Review Agrochemicals: Composition, Production, Toxicology, Applications. Edited by Franz Müller
Molecules 2000, 5(5), 712-713; doi:10.3390/50500712
Received: 25 March 2000 / Published: 25 May 2000
PDF Full-text (5 KB)

Journal Contact

MDPI AG
Molecules Editorial Office
St. Alban-Anlage 66, 4052 Basel, Switzerland
molecules@mdpi.com
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
Editorial Board
Contact Details Submit to Molecules
Back to Top