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Displaying article 1-8
p. 701-709
Received: 3 August 1999; in revised form: 13 October 1999 / Accepted: 13 October 1999 / Published: 5 May 2000
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| Download PDF Full-text (42 KB) Abstract: Phenylsulfonylacetonitrile (1) when reacted with α,β-unsaturated nitriles (2a,b) and/or 2-hydroxynaphthaldehyde yields pyridine derivatives (3a,b) and / or the iminochromene derivative (4) respectively. The behavior of (1) towards some a-halogenated compounds has been investigated.
p. 710-711
Received: 18 March 2000 / Published: 23 April 2000
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p. 712-713
Received: 25 March 2000 / Published: 25 May 2000
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p. 714-726
Received: 2 November 1999 / Accepted: 13 December 1999 / Published: 14 May 2000
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| Download PDF Full-text (42 KB) Abstract: A set of N,N'-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N'-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacterially active substances were found only in the series of N,N'-diarylethanediamides and N,N'-diarylbutanediamides. Other compounds (derivatives of pentane-, hexane-, octane- and nonanediamide) were inactive against various strains of mycobacteria. The compounds inhibited growth and chlorophyll production in Chlorella vulgaris . Their relatively low antialgal activity is probably connected with their lowered aqueous solubility, and hence by a restricted passage of the inhibitor through the hydrophilic regions of thylakoid membranes.
p. 727-729
Received: 4 May 2000 / Accepted: 10 May 2000 / Published: 15 May 2000
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| Download PDF Full-text (17 KB) Abstract: We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with potential application in gene therapy.
p. 730-736
Received: 10 January 2000 / Accepted: 10 May 2000 / Published: 18 April 2000
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| Download PDF Full-text (38 KB) Abstract: The synthesis of a water soluble azo initiators from 2,2’-azodiisobutyronitrile (AIBN) was performed in three steps: reaction of dinitrile with aromatic alcohols in the presence of HCl to form bisiminoesters hydrochlorides which are hydrolyzed to the esters and final regioselective sulfonation of the aromatic esters. The thermal decomposition of the azo initiators obtained leads to formation of two surface active radicals which can start the chain reaction.
p. 737-745
Received: 6 September 1999; in revised form: 7 November 1999 / Accepted: 7 February 2000 / Published: 20 May 2000
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| Download PDF Full-text (35 KB) Abstract: Z- and E-isomers of 5-alkyl-4-ethoxycarbonyl-5-(4`-chlorophenyl)-3-oxa-4-pentenoic acids were prepared via the condensation of p-chloroacetophenone and/or pchloropropiophenone with diethyl-2,2`-oxydiacetate in the presence of sodium hydride as a basic catalyst. The Z-isomers of 2a and 2b were found to be predominant. The behaviour of the corresponding anhydrides towards the action of hydrazine, phenylhydrazine, primary aromatic amines, hydrocarbons and ethanolysis has also been investigated. The structures and configurations of the products have been elucidated by chemical and spectroscopic means.
p. 746-755
Received: 6 September 1999; in revised form: 15 December 1999 / Accepted: 12 February 2000 / Published: 20 May 2000
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| Download PDF Full-text (262 KB) Abstract: The effect of some active methylene containing heterocyclic compounds, namely barbituric acid, thiobarbituric acid and 3-methyl-1-phenylpyrazol-5-one on a-cyano-3,4,5-trimethoxycinnamonitrile and ethyl a-cyano-3,4,5-trimethoxycinnamate (1a,b) was investigated. The structure of the new products was substantiated by their IR,1 H-NMR and mass spectra.
Displaying article 1-8
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