Molecules

102 KiB

Open AccessShort Note

A New Heterocyclization Product of Adhyperforin from Hypericum perforatum (St. John's Wort)

by Suzana Vugdelija, Vlatka Vajs, Snezana Trifunovic, Dejan Djokovic and Slobodan Milosavljevic

Molecules 2000, 5(4), M158; https://doi.org/10.3390/M158 - 30 Apr 2000

Cited by 8 | Viewed by 4369

From the aerial parts of Hypericum perforatum L. we have isolated phloroglucinol 1 (see the formula), a homologue of 2, the latter isolated previously from the same extract and identified by 2D NMR (DQF COSY, PS NOESY, TOCSY, HSQC and HMBC) [1].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

87 KiB

Open AccessShort Note

Menthyl 2-Benzyl-2-phenylsulfonyl Acetate

by Mohammed Ramdani and Abderrahmane Elidrissi

Molecules 2000, 5(4), M146; https://doi.org/10.3390/M146 - 29 Apr 2000

Viewed by 2790

Abstract

The product 2 was prepared from menthyl phenylsulfonyl acetate in situ by the solid-liquid PTC conditions without solvent.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

85 KiB

Open AccessShort Note

N,N-Dibutyl-2-p-tolyl-acetamide

by Olivier Comte, Sylvie Genillard and Céline Nkubana

Molecules 2000, 5(4), M161; https://doi.org/10.3390/M161 - 28 Apr 2000

Viewed by 3042

Abstract

Thionyl chloride (2.18 ml, 3.56 g, 30 mmol, 1.5 eq) was added dropwise to a vigorously stirred solution of p-tolylacetic acid (3 g, 20 mmol, 1 eq) and heated to 100°C for 3 hours.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

88 KiB

Open AccessShort Note

2-Chloro-3-(4-morpholino)-1,4-naphthoquinone

by Sukanta Bhattacharyya

Molecules 2000, 5(4), M160; https://doi.org/10.3390/M160 - 28 Apr 2000

Cited by 3 | Viewed by 3477

Abstract

The title compound, a novel electron donor-acceptor system [1] was prepared [2] by refluxing a suspension of commercially available 2,3-dichloro-1,4-naphthoquinone in absolute ethanol and morpholine in the presence of anhydrous potassium carbonate.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

91 KiB

Open AccessShort Note

1-(N,N-Dimethylamino)adamantane

by Sukanta Bhattacharyya

Molecules 2000, 5(4), M159; https://doi.org/10.3390/M159 - 28 Apr 2000

Cited by 2 | Viewed by 3198

Abstract

The title compound, an important antiviral agent [1] was prepared from commercially available 1-aminoadamantane by titanium(IV) isopropoxide mediated reductive amination of formaldehyde [2].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

91 KiB

Open AccessShort Note

1-[(2-Acetoxyethoxy)methyl]-3-ethoxycarbonylmethyl-5-bromo-6-azauracil

by Smaail Radi and Hassan B. Lazrek

Molecules 2000, 5(4), M157; https://doi.org/10.3390/M157 - 28 Apr 2000

Viewed by 2896

Abstract

The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

91 KiB

Open AccessShort Note

1-[(2-Acetoxyethoxy)methyl]-3-allyl-5-bromo-6-azauracil

by Smaail Radi and Hassan B. Lazrek

Molecules 2000, 5(4), M156; https://doi.org/10.3390/M156 - 28 Apr 2000

Viewed by 2506

Abstract

The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

91 KiB

Open AccessShort Note

1-[(2-Acetoxyethoxy)methyl]-3-benzyl-5-bromo-6-azauracil

by Smaail Radi and Hassan B. Lazrek

Molecules 2000, 5(4), M155; https://doi.org/10.3390/M155 - 28 Apr 2000

Viewed by 2945

Abstract

The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

91 KiB

Open AccessShort Note

1-[(2-Acetoxyethoxy)methyl]-3-ethyl-5-bromo-6-azauracil

by Smaail Radi and Hassan B. Lazrek

Molecules 2000, 5(4), M154; https://doi.org/10.3390/M154 - 28 Apr 2000

Viewed by 2503

Abstract

The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

91 KiB

Open AccessShort Note

1-[(2-Acetoxyethoxy)methyl]-3-methyl-5-bromo-6-azauracil

by Smaail Radi and Hassan B. Lazrek

Molecules 2000, 5(4), M153; https://doi.org/10.3390/M153 - 28 Apr 2000

Viewed by 2520

Abstract

The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

90 KiB

Open AccessShort Note

1-[(2-Acetoxyethoxy)methyl]-3-ethoxycarbonylmethyl-6-azauracil

by Smaail Radi and Hassan B. Lazrek

Molecules 2000, 5(4), M152; https://doi.org/10.3390/M152 - 28 Apr 2000

Viewed by 2571

Abstract

The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

91 KiB

Open AccessShort Note

1-[(2-Acetoxyethoxy)methyl]-3-allyl-6-azauracil

by Smaail Radi and Hassan B. Lazrek

Molecules 2000, 5(4), M151; https://doi.org/10.3390/M151 - 28 Apr 2000

Viewed by 2493

Abstract

The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

90 KiB

Open AccessShort Note

1-[(2-Acetoxyethoxy)methyl]-3-benzyl-6-azauracil

by Smaail Radi and Hassan B. Lazrek

Molecules 2000, 5(4), M150; https://doi.org/10.3390/M150 - 28 Apr 2000

Viewed by 2531

Abstract

The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

90 KiB

Open AccessShort Note

1-[(2-Acetoxyethoxy)methyl]-3-ethyl-6-azauracil

by Smaail Radi and Hassan B. Lazrek

Molecules 2000, 5(4), M149; https://doi.org/10.3390/M149 - 28 Apr 2000

Viewed by 2577

Abstract

The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

222 KiB

Open AccessShort Note

1-[(2-Acetoxyethoxy)methyl]-3-methyl-6-azauracil

by Smaail Radi and Hassan B. Lazrek

Molecules 2000, 5(4), M148; https://doi.org/10.3390/M148 - 28 Apr 2000

Viewed by 2852

Abstract

The product 2 was prepared via a direct condensation under solid-liquid phase transfer catalysis (S.L.P.T.C.) [1] conditions.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

88 KiB

Open AccessShort Note

2,4,6-Tris(2',4',6'-trimethylphenylethynyl)mesitylene

by Laura Jeffries and Eric Bosch

Molecules 2000, 5(4), M147; https://doi.org/10.3390/M147 - 28 Apr 2000

Viewed by 2432

Abstract

The experimental procedure follows the general synthesis of arylalkynes reported by Sonogashira [1].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

84 KiB

Open AccessShort Note

Menthyl Phenylsulfonyl Acetate

by Mohammed Ramdani and Abderrahmane Elidrissi

Molecules 2000, 5(4), M145; https://doi.org/10.3390/M145 - 28 Apr 2000

Viewed by 3009

Abstract

Menthyl phenylsulfonyl acetate was prepared from methyl phenylsulfonyl acetate by solid-liquid PTC trans-esterification conditions without a solvent [1].[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

93 KiB

Open AccessShort Note

6-S-Trityl-mercapto-hexan-1-ol

by Zoltán Kupihár, Zoltán Schmél and Lajos Kovács

Molecules 2000, 5(4), M144; https://doi.org/10.3390/M144 - 28 Apr 2000

Cited by 3 | Viewed by 4535

Abstract

6-S-Trityl-mercapto-hexan-1-ol is an important compound, because its O-b-cyanoethyl-N,N-diisopropyl phosphoramidite derivative is the most widely used building block for the synthesis of 5'-thiol modified oligonucleotides.[...] Full article

(This article belongs to the Section Molbank Section of Molecules, 1997-2001)

5 KiB

Open AccessBook Review

Basic Mathematics for Biochemists. by Athel Cornish-Bowden

by Shu-Kun Lin

Molecules 2000, 5(4), 699-700; https://doi.org/10.3390/50400699 - 26 Apr 2000

Viewed by 4302

Abstract

This is a new edition of the book published under the same title by Chapman and Hall in 1981.[...] Full article

107 KiB

Open AccessArticle

Synthesis of a Highly Functionalized Triquinane: Studies Towards a Total Synthesis of Subergorgic Acid and Its Analogues

by Veljko Dragojlovic

Molecules 2000, 5(4), 674-698; https://doi.org/10.3390/50400674 - 20 Apr 2000

Cited by 9 | Viewed by 7601

Abstract

Reaction of enone (11) with the bifunctional Grignard reagent (7) in the presence of copper(I) bromide – dimethyl sulfide, followed by intramolecular alkylation of the resultant chloroketone (15) gave the tricyclic ketone (12). The tricyclic ketone (12) was transformed into the angular triquinane [...] Read more.

Reaction of enone (11) with the bifunctional Grignard reagent (7) in the presence of copper(I) bromide – dimethyl sulfide, followed by intramolecular alkylation of the resultant chloroketone (15) gave the tricyclic ketone (12). The tricyclic ketone (12) was transformed into the angular triquinane dienedione (9) by means of an 8-step sequence. Full article

► Show Figures

Figure 1

52 KiB

Open AccessArticle

Facile Synthesis of (R,R) and of (R,S) Tricarballylic Acid Anhydride and Imide Derivatives

by Abdel-Sattar S. Hamad Elgazwy

Molecules 2000, 5(4), 665-673; https://doi.org/10.3390/50400665 - 15 Apr 2000

Cited by 6 | Viewed by 7952

Abstract

The diastereomeric mixture of (R)-2-(methoxycarbonylmethyl)-N-(R)-1-(1-phenylethyl) succinimide 11s and (S)-2-(methoxycarbonylmethyl)-N-(R)-1-(1-phenylethyl) succinimide 11a was synthesized by reaction of 2-(carboxymethyl)succinic anhydride 6 with (R)-(α)-methylbenzylamine in dry THF/room temperature/24 hrs. The diastereomeric mixture of 1-[(R)-(α)-Methylbenzylamideformyl)]propane-2,3-dicarboxylic [...] Read more.

The diastereomeric mixture of (R)-2-(methoxycarbonylmethyl)-N-(R)-1-(1-phenylethyl) succinimide 11s and (S)-2-(methoxycarbonylmethyl)-N-(R)-1-(1-phenylethyl) succinimide 11a was synthesized by reaction of 2-(carboxymethyl)succinic anhydride 6 with (R)-(α)-methylbenzylamine in dry THF/room temperature/24 hrs. The diastereomeric mixture of 1-[(R)-(α)-Methylbenzylamideformyl)]propane-2,3-dicarboxylic acid anhydride 9s and 1-[(R)-(α)-methylbenzylamideformyl)]propane-2,3-dicarboxylic acid anhydride 9a was isolated as an intermediate under the reaction conditions. This diastereomeric mixture 9s/9a was also prepared by a different route via reaction of 1-(chloroformyl)propane-2,3-dicarboxylic acid anydride 12 with (R)-(α)-methylbenzylamine in the presence of DMA at 0^oC for 24 hrs. Full article

► Show Figures

Figure 1

25 KiB

Open AccessArticle

Thermolysis of Semicarbazones to the Corresponding Azines Through Reactive N-Substituted Isocyanate Intermediates

by S. N. Shah and N. K. Chudgar

Molecules 2000, 5(4), 657-664; https://doi.org/10.3390/50400657 - 07 Apr 2000

Cited by 27 | Viewed by 6790

Abstract

Thermolysis of semicarbazones (I) to azines (II) occurs through reactive N-substituted isocyanate intermediates (Ia) which can be converted in situ to carbamates and Nsubstituted ureas. Full article

► Show Figures

Scheme 1

10 KiB

Open AccessArticle

Synthesis and Elastase Inhibitory Evaluation of Phosphate Esters and Mixed Phosphate Anhydride of Penam Sulfones

by María A. Laborde and O. A. Mascaretti

Molecules 2000, 5(4), 655-656; https://doi.org/10.3390/50400655 - 05 Apr 2000

Viewed by 5856

Abstract

The evaluation of human leucocite elastase inhibition by phosphate esters (1-2) and phosphate mixed anhydride (3) of penicillin sulfones and their precursor sulfides is described. Full article

28 KiB

Open AccessArticle

Insecticidal Activity of Cyanohydrin and Monoterpenoid Compounds

by Chris J. Peterson, Rong Tsao, Aimee L. Eggler and Joel R. Coats

Molecules 2000, 5(4), 648-654; https://doi.org/10.3390/50400648 - 03 Apr 2000

Cited by 38 | Viewed by 8801

Abstract

The insecticidal activities of several cyanohydrins, cyanohydrin esters and monoterpenoid esters (including three monoterpenoid esters of a cyanohydrin) were evaluated. Topical toxicity to Musca domestica L. adults was examined, and testing of many compounds at 100 mg/fly resulted in 100% mortality. Topical LD [...] Read more.

The insecticidal activities of several cyanohydrins, cyanohydrin esters and monoterpenoid esters (including three monoterpenoid esters of a cyanohydrin) were evaluated. Topical toxicity to Musca domestica L. adults was examined, and testing of many compounds at 100 mg/fly resulted in 100% mortality. Topical LD₅₀ values of four compounds for M. domestica were calculated. Testing of many of the reported compounds to brine shrimp (Artemia franciscana Kellog) resulted in 100% mortality at 10 ppm, and two compounds caused 100% mortality at 1 ppm. Aquatic LC₅₀ values were calculated for five compounds for larvae of the yellow fever mosquito (Aedes aegypti (L.)). Monoterpenoid esters were among the most toxic compounds tested in topical and aquatic bioassays. Full article

► Show Figures

Figure 1

121 KiB

Open AccessArticle

Cycloaddition Reactions of C,N-Diphenylnitrone to Methylene-γ-butyrolactones

by Martina Cacciarini, Franca M. Cordero, Cristina Faggi and Andrea Goti

Molecules 2000, 5(4), 637-647; https://doi.org/10.3390/50400637 - 02 Apr 2000

Cited by 20 | Viewed by 9145

Abstract

Cycloaddition of C,N-diphenylnitrone to α-methylene-γ-butyrolactone afforded two diastereomeric 5-spirosubstituted isoxazolidines with high selectivity. Structural assignment was ascertained by NMR studies and an X-ray diffraction experiment on a single crystal of the major isomer and the diastereoselectivity was rationalized on examination of the alternative [...] Read more.

Cycloaddition of C,N-diphenylnitrone to α-methylene-γ-butyrolactone afforded two diastereomeric 5-spirosubstituted isoxazolidines with high selectivity. Structural assignment was ascertained by NMR studies and an X-ray diffraction experiment on a single crystal of the major isomer and the diastereoselectivity was rationalized on examination of the alternative transition states leading to the two diastereoisomers. Full article

► Show Figures

Figure 1

Journal Menu

Journal Browser

Molecules, Volume 5, Issue 4 (April 2000) – 25 articles , Pages 637-700, Articles M144-M161

Further Information

Guidelines

MDPI Initiatives

Follow MDPI