Molecules 2000, 5(5), 727-729; doi:10.3390/50500727
Article

Synthesis of 2’-Modified Nucleotides

Mariana Gallo 1,* email, Héctor Torres 1  and Adolfo Iribarren 1,2
1 Instituto de Investigación en Ingeniería Genética y Biología Molecular, UBA - CONICET. Vuelta de Obligado 2490 2°P (1428). Buenos Aires, Argentine 2 Centro de Estudios e Investigaciones. Universidad Nacional de Quilmes. Roque Saenz Pena 180 (1876). Prov. Buenos Aires, Argentine
* Author to whom correspondence should be addressed.
Received: 4 May 2000 / Accepted: 10 May 2000 / Published: 15 May 2000
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Abstract: We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with potential application in gene therapy.
Keywords: Modified nucleotides; ribozymes

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Cite This Article

MDPI and ACS Style

Gallo, M.; Torres, H.; Iribarren, A. Synthesis of 2’-Modified Nucleotides. Molecules 2000, 5, 727-729.

AMA Style

Gallo M, Torres H, Iribarren A. Synthesis of 2’-Modified Nucleotides. Molecules. 2000; 5(5):727-729.

Chicago/Turabian Style

Gallo, Mariana; Torres, Héctor; Iribarren, Adolfo. 2000. "Synthesis of 2’-Modified Nucleotides." Molecules 5, no. 5: 727-729.

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