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Molecules 2000, 5(5), 727-729; doi:10.3390/50500727

Synthesis of 2’-Modified Nucleotides

1,* , 1 and 1,2
1 Instituto de Investigación en Ingeniería Genética y Biología Molecular, UBA - CONICET. Vuelta de Obligado 2490 2°P (1428). Buenos Aires, Argentine 2 Centro de Estudios e Investigaciones. Universidad Nacional de Quilmes. Roque Saenz Pena 180 (1876). Prov. Buenos Aires, Argentine
* Author to whom correspondence should be addressed.
Received: 4 May 2000 / Accepted: 10 May 2000 / Published: 15 May 2000
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We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with potential application in gene therapy.
Keywords: Modified nucleotides; ribozymes Modified nucleotides; ribozymes
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Gallo, M.; Torres, H.; Iribarren, A. Synthesis of 2’-Modified Nucleotides. Molecules 2000, 5, 727-729.

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