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Molecules 2000, 5(5), 727-729; doi:10.3390/50500727
Article

Synthesis of 2’-Modified Nucleotides

1,* , 1 and 1,2
1 Instituto de Investigación en Ingeniería Genética y Biología Molecular, UBA - CONICET. Vuelta de Obligado 2490 2°P (1428). Buenos Aires, Argentine 2 Centro de Estudios e Investigaciones. Universidad Nacional de Quilmes. Roque Saenz Pena 180 (1876). Prov. Buenos Aires, Argentine
* Author to whom correspondence should be addressed.
Received: 4 May 2000 / Accepted: 10 May 2000 / Published: 15 May 2000
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Abstract

We show in this work the development of modified building blocks for the synthesis of nuclease resistant hammerhead ribozymes. These modified monomers retain the 2’-OH which is essential for the activity of these molecules. Our final goal is to generate a catalytic antisense approach with potential application in gene therapy.
Keywords: Modified nucleotides; ribozymes Modified nucleotides; ribozymes
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Gallo, M.; Torres, H.; Iribarren, A. Synthesis of 2’-Modified Nucleotides. Molecules 2000, 5, 727-729.

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