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Agrochemicals: Composition, Production, Toxicology, Applications. Edited by Franz Müller
Molecules 2000, 5(5), 714-726; doi:10.3390/50500714
Article

Synthesis of N,N’-Diarylalkanediamides and Their Antimycobacterial and Antialgal Activity

1,* , 1, 2, 3, 4, 5, 5 and 6
Received: 2 November 1999 / Accepted: 13 December 1999 / Published: 14 May 2000
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Abstract

A set of N,N'-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N'-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacterially active substances were found only in the series of N,N'-diarylethanediamides and N,N'-diarylbutanediamides. Other compounds (derivatives of pentane-, hexane-, octane- and nonanediamide) were inactive against various strains of mycobacteria. The compounds inhibited growth and chlorophyll production in Chlorella vulgaris. Their relatively low antialgal activity is probably connected with their lowered aqueous solubility, and hence by a restricted passage of the inhibitor through the hydrophilic regions of thylakoid membranes.
Keywords: N; N'-diarylalkanediamides; antimycobacterial activity; antialgal activity N; N'-diarylalkanediamides; antimycobacterial activity; antialgal activity
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Kubicova, L.; Waisser, K.; Kunes, J.; Kralova, K.; Odlerova, Z.; Slosarek, M.; Janota, J.; Svoboda, Z. Synthesis of N,N’-Diarylalkanediamides and Their Antimycobacterial and Antialgal Activity. Molecules 2000, 5, 714-726.

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