Next Article in Journal
Synthesis of 2’-Modified Nucleotides
Previous Article in Journal
Agrochemicals: Composition, Production, Toxicology, Applications. Edited by Franz Müller
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2000, 5(5), 714-726; doi:10.3390/50500714

Synthesis of N,N’-Diarylalkanediamides and Their Antimycobacterial and Antialgal Activity

1
Department of Inorganic and Organic Chemistry, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
2
Laboratory of Structure and Interactions of Biologically Active Molecules, Charles University in Prague, Faculty of Pharmacy in Hradec Kralove, Heyrovskeho 1203, 500 05 Hradec Kralove, Czech Republic
3
Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina CH-2, 842 15 Bratislava, Slovak Republic
4
Institute of Preventive and Clinic Medicine, Limbova 14, 835 01 Bratislava, Slovak Republic
5
National Institute of Public Health, Srobarova 48, 100 42 Praha 10, Czech Republic
6
Institute of Experimental Biopharmaceutics, Heyrovskeho 1207, 500 02 Hradec Kralove, Czech Republic
*
Author to whom correspondence should be addressed.
Received: 2 November 1999 / Accepted: 13 December 1999 / Published: 14 May 2000
Download PDF [42 KB, uploaded 18 June 2014]

Abstract

A set of N,N'-diarylalkanediamides was synthesized. The compounds were tested for their antimycobacterial and antialgal activity. The antimycobacterial activity of N,N'-diarylalkanediamides depends on the lipophilicity of the respective acid. Antimycobacterially active substances were found only in the series of N,N'-diarylethanediamides and N,N'-diarylbutanediamides. Other compounds (derivatives of pentane-, hexane-, octane- and nonanediamide) were inactive against various strains of mycobacteria. The compounds inhibited growth and chlorophyll production in Chlorella vulgaris. Their relatively low antialgal activity is probably connected with their lowered aqueous solubility, and hence by a restricted passage of the inhibitor through the hydrophilic regions of thylakoid membranes.
Keywords: N; N'-diarylalkanediamides; antimycobacterial activity; antialgal activity N; N'-diarylalkanediamides; antimycobacterial activity; antialgal activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kubicova, L.; Waisser, K.; Kunes, J.; Kralova, K.; Odlerova, Z.; Slosarek, M.; Janota, J.; Svoboda, Z. Synthesis of N,N’-Diarylalkanediamides and Their Antimycobacterial and Antialgal Activity. Molecules 2000, 5, 714-726.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top