Next Issue
Previous Issue

E-Mail Alert

Add your e-mail address to receive forthcoming issues of this journal:

Journal Browser

Journal Browser

Table of Contents

Molecules, Volume 5, Issue 10 (October 2000), Pages 1080-1181

  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list.
  • You may sign up for e-mail alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Readerexternal link to open them.
View options order results:
result details:
Displaying articles 1-12
Export citation of selected articles as:

Research

Jump to: Other

Open AccessArticle Interaction of 1,5-Substituted Pyrrolin-2-ones with Dichlorocarbene under Phase Transfer Catalysis Conditions
Molecules 2000, 5(10), 1082-1084; doi:10.3390/51001082
Received: 14 December 1999 / Revised: 27 April 2000 / Accepted: 20 September 2000 / Published: 31 October 2000
Cited by 1 | PDF Full-text (15 KB)
Abstract Treatment of 5-alkyl(aryl)-3H-pyrrolin-2-ones with dichlorocarbene under phase transfer catalysis conditions at 20-30ºC results in a cycloaddition of the carbene to the C=C bond followed by skeletal rearrangement. Full article
Open AccessArticle Synthesis and Reactions of Substituted 3-amino-2-furyl(aryl)-thieno[2,3-b]pyridines
Molecules 2000, 5(10), 1085-1093; doi:10.3390/51001085
Received: 15 November 1999 / Revised: 29 August 2000 / Accepted: 20 September 2000 / Published: 31 October 2000
Cited by 8 | PDF Full-text (37 KB)
Abstract New substituted thieno[2,3-b]pyridines which contain 4-nitropehnyl and 5-nitro-, carboxy-, methoxycarbonyl-2-furyl groups in the 2 position have been obtained. Full article
Open AccessArticle Synthesis of Regioselectively Protected Protocatechuic Acid Derivatives by Biomimetic Transformation of Quinic Acid
Molecules 2000, 5(10), 1094-1100; doi:10.3390/51001094
Received: 7 April 2000 / Revised: 11 September 2000 / Accepted: 19 September 2000 / Published: 31 October 2000
PDF Full-text (74 KB)
Abstract 3- and 4-monoesterified protocatechuic acid methyl ester (5 and 7 respectively) have been synthesised from quinic acid by a high yields biomimetic rearrangement. Full article
Open AccessArticle Synthesis of Novel 1-Substituted and 1,9-Disubstituted-1,2,3,4-tetrahydro-9H-Carbazole Derivatives as Potential Anticancer Agents
Molecules 2000, 5(10), 1101-1112; doi:10.3390/51001101
Received: 22 February 2000 / Revised: 21 July 2000 / Accepted: 28 August 2000 / Published: 31 October 2000
Cited by 3 | PDF Full-text (53 KB)
Abstract
Condensation of 1-acetyl-1,2,3,4-tetrahydro-9H-carbazole (2) with some amino compounds furnished the corresponding imino derivatives 3a-e. Compound 3a reacted with chloroacetic acid and underwent cyclization to give the thiazolidine derivative 5. Also, treatment of 3c with thionyl chloride caused cyclization to yield the [1,2,6]thiadiazino derivative
[...] Read more.
Condensation of 1-acetyl-1,2,3,4-tetrahydro-9H-carbazole (2) with some amino compounds furnished the corresponding imino derivatives 3a-e. Compound 3a reacted with chloroacetic acid and underwent cyclization to give the thiazolidine derivative 5. Also, treatment of 3c with thionyl chloride caused cyclization to yield the [1,2,6]thiadiazino derivative 6, which gave the corresponding N-formyl derivative 7 upon heating with ethyl formate. In addition, interaction of 3d with ethyl cyanoacetate yielded the monoamide of malonic acid derivative 8. Acylation of carbazole 1 with succinoyl chloride or phenylacetyl choride produced the corresponding azepine (11) and 1,9-diphenyl acetyl derivatives (14), respectively. Compounds 11, 14 were further reacted to give the carbazole derivatives 12, 13 and 15a,b. The cytotoxic activity for some of the prepared compounds against breast cancer B20 is discussed. Full article
Open AccessArticle Crystal Structure of Methyl 4-amino-4-cyano-4,6-dideoxy-2,3-O-isopropylidene-α-L-talopyranoside
Molecules 2000, 5(10), 1113-1120; doi:10.3390/51001113
Received: 29 May 2000 / Revised: 7 September 2000 / Accepted: 26 September 2000 / Published: 31 October 2000
PDF Full-text (162 KB)
Abstract
The structure of methyl 4-amino-4-cyano-4,6-dideoxy-2,3-O-isopropylidene-α-Ltalopyranoside was established by X-ray analysis confirming a talo configuration at C-4 and suggesting a 1C4 conformation of the pyranose ring. The values of relevant torsion angles and calculated puckering parameters revealed a distortion into
[...] Read more.
The structure of methyl 4-amino-4-cyano-4,6-dideoxy-2,3-O-isopropylidene-α-Ltalopyranoside was established by X-ray analysis confirming a talo configuration at C-4 and suggesting a 1C4 conformation of the pyranose ring. The values of relevant torsion angles and calculated puckering parameters revealed a distortion into the direction of 5E conformation, thus indicating a flattening at C-2. Full article
Open AccessArticle Studies On Some Acid Divalent-Metal Nitrilotriacetate Complexes
Molecules 2000, 5(10), 1121-1129; doi:10.3390/51001121
Received: 7 July 2000 / Revised: 23 August 2000 / Accepted: 20 September 2000 / Published: 31 October 2000
Cited by 20 | PDF Full-text (84 KB)
Abstract
IR and 1H-NMR studies on nitrilotriacetic acid (H3NTA) suggest that the acid exists in the zwitterion form, which allows the existence of intermolecular hydrogen bonding. A tetrahedral structure is established for eleven (1:1) anhydrous acid-metal (II) nitrilotriacetates complexes. The ten
[...] Read more.
IR and 1H-NMR studies on nitrilotriacetic acid (H3NTA) suggest that the acid exists in the zwitterion form, which allows the existence of intermolecular hydrogen bonding. A tetrahedral structure is established for eleven (1:1) anhydrous acid-metal (II) nitrilotriacetates complexes. The ten Dq values for the colored complexes were determined spectrophotometrically. The pKa values for the eleven acid metal complexes [M(HNTA)].(OH2)3] were determined and compared with the corresponding pKa values of the [M(OH2)n]+2 ions and also with the log β1 values of the corresponding [M(NTA)]- complexes. X-ray diffraction studies on the ligand and on eight of these complexes are described. Full article
Open AccessArticle Application of Flow Thermolysis in Organic Synthesis: Easy Access to α,ω-Bis Thienyl- and Bis Pyrrolyl- Alkanes from Methylene Derivatives of Meldrum's Acid
Molecules 2000, 5(10), 1130-1138; doi:10.3390/51001130
Received: 21 July 2000 / Revised: 26 September 2000 / Accepted: 27 September 2000 / Published: 31 October 2000
Cited by 1 | PDF Full-text (43 KB)
Abstract Thermal decomposition of Meldrum's acid derivatives and rearrangement of (alkylsulfanyl) or (propargylamino)methylene ketene intermediates leads in one step to bis thienyl- or bis pyrrolyl-alkanes. Full article
Open AccessArticle Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate
Molecules 2000, 5(10), 1139-1145; doi:10.3390/51001139
Received: 26 July 2000 / Revised: 21 September 2000 / Accepted: 28 September 2000 / Published: 31 October 2000
Cited by 3 | PDF Full-text (41 KB)
Abstract The E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassium carbonate in DMF. Full article
Open AccessArticle A New Pathway to 3-Hetaryl-2-oxo-2H-chromenes: On the Proposed Mechanisms for the Reaction of 3-Carbamoyl-2-iminochromenes with Dinucleophiles
Molecules 2000, 5(10), 1146-1165; doi:10.3390/51001146
Received: 30 July 2000 / Accepted: 19 September 2000 / Published: 31 October 2000
Cited by 21 | PDF Full-text (431 KB)
Abstract The present account summarizes the author's studies to elucidate the mechanisms of the recently reported rearrangements resulting from inter- and/or intramolecular reactions of 2-imino-2H-chromene-3-carboxamides with different dinucleophiles. Full article
Open AccessArticle One-pot Syntheses of Fused Quinazolines by Reaction of N-(2-Cyanophenyl)chloromethanimidoyl Chloride. I. A New Synthesis of 1,3-Oxazolo- and 1,3-Oxazino[2,3-b]quinazolines
Molecules 2000, 5(10), 1166-1174; doi:10.3390/51001166
Received: 14 August 2000 / Revised: 13 September 2000 / Accepted: 19 September 2000 / Published: 31 October 2000
Cited by 9 | PDF Full-text (130 KB)
Abstract
12H-Benzo[1,3]oxazolo[2,3-b]quinazolin-12-imine (5a), 9-chloro-12Hbenzo[1,3]oxazolo[2,3-b]quinazolin-12-imine (5b), 2,3-dihydro-5H-[1,3]oxazolo[2,3-b]quinazolin-5-imine (5c), 2,3-dihydro-3,3-dimethyl-5H-[1,3]oxazolo[2,3-b]quinazolin-5-imine (5d) and 3,4--dihydro-2H,6H-[1,3]oxazino[2,3-b]quinazolin-6-imine (5e) were synthesized in a one-pot reaction of N-(2-cyanophenyl)chloromethanimidoyl chloride (1) with 2-aminophenols, 2-aminoethanol, and 3-aminopropanol in the presence of
[...] Read more.
12H-Benzo[1,3]oxazolo[2,3-b]quinazolin-12-imine (5a), 9-chloro-12Hbenzo[1,3]oxazolo[2,3-b]quinazolin-12-imine (5b), 2,3-dihydro-5H-[1,3]oxazolo[2,3-b]quinazolin-5-imine (5c), 2,3-dihydro-3,3-dimethyl-5H-[1,3]oxazolo[2,3-b]quinazolin-5-imine (5d) and 3,4--dihydro-2H,6H-[1,3]oxazino[2,3-b]quinazolin-6-imine (5e) were synthesized in a one-pot reaction of N-(2-cyanophenyl)chloromethanimidoyl chloride (1) with 2-aminophenols, 2-aminoethanol, and 3-aminopropanol in the presence of a base. The course of the reaction was controlled by the temperature and the amount of base used. N-(2-Cyanophenyl)-(2-hydroxyanilino)methanimidoyl chloride (3a), 2-chloro-3-(2-hydroxyphenyl)-3,4-dihydroquinazolin-4-imine (4a) and 6-imino-2H, 3H, 4H, 6H, 11H-1,3-oxazino[2,3-b]-5-quinazolinium chloride (6) were identified as intermediates of the one-pot process. Full article
Open AccessArticle Regioselective Oxidation of 3-Substituted Pyridinium Salts
Molecules 2000, 5(10), 1175-1181; doi:10.3390/51001175
Received: 18 August 2000 / Revised: 3 October 2000 / Accepted: 4 October 2000 / Published: 31 October 2000
PDF Full-text (58 KB)
Abstract (1'R)-(+)-3-Hydroxymethyl-1-(1'-phenyl-ethyl)-pyridinium chloride (1), 1-benzyl-3-[1', 3']-dioxolan-2'-yl-pyridinium chloride (2) and (2'S, 4'S, 5'R)-(-)-1-benzyl-3-(3',4'-dimethyl-5'-phenyl-oxazolidin-2'-yl)-pyridinium bromide (3), were transformed by oxidation with potassium ferricyanide into the corresponding 1H-pyridin-2-ones in excellent yields with high regioselectivity. Full article

Other

Jump to: Research

Open AccessCommentary Free Access or Free Publication
Molecules 2000, 5(10), 1080-1081; doi:10.3390/51001080
Received: 30 September 2000 / Published: 13 October 2000
PDF Full-text (20 KB)

Journal Contact

MDPI AG
Molecules Editorial Office
St. Alban-Anlage 66, 4052 Basel, Switzerland
molecules@mdpi.com
Tel. +41 61 683 77 34
Fax: +41 61 302 89 18
Editorial Board
Contact Details Submit to Molecules
Back to Top