Next Article in Journal
A New Pathway to 3-Hetaryl-2-oxo-2H-chromenes: On the Proposed Mechanisms for the Reaction of 3-Carbamoyl-2-iminochromenes with Dinucleophiles
Previous Article in Journal
Application of Flow Thermolysis in Organic Synthesis: Easy Access to α,ω-Bis Thienyl- and Bis Pyrrolyl- Alkanes from Methylene Derivatives of Meldrum's Acid
Molecules 2000, 5(10), 1139-1145; doi:10.3390/51001139
Article

Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate

1, 2, 1,* , 3 and 2
1 Laboratoire de Chimie Bioorganique, Faculté des Sciences Semlalia, Marrakech, Marocco 2 Faculté des Sciences et Techniques Gueliz, BP : 618, 40 000, Marrakech, Marocco 3 Laboratoire de Chimie Bioorganique, Université des Sciences et Techniques Montpellier II, Montpellier, France
* Author to whom correspondence should be addressed.
Received: 26 July 2000 / Revised: 21 September 2000 / Accepted: 28 September 2000 / Published: 31 October 2000
Download PDF [41 KB, uploaded 18 June 2014]

Abstract

The E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassium carbonate in DMF.
Keywords: Acyclonucleoside; Phophonoalkenyl; Michael addition; N-3-alkylation Acyclonucleoside; Phophonoalkenyl; Michael addition; N-3-alkylation
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Rochdi, A.; Taourirte, M.; Lazrek, H.B.; Barascut, J.L.; Imbach, J.L. Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate. Molecules 2000, 5, 1139-1145.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert