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Molecules 2000, 5(10), 1139-1145; doi:10.3390/51001139
Article

Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate

1, 2, 1,* , 3 and 2
1 Laboratoire de Chimie Bioorganique, Faculté des Sciences Semlalia, Marrakech, Marocco 2 Faculté des Sciences et Techniques Gueliz, BP : 618, 40 000, Marrakech, Marocco 3 Laboratoire de Chimie Bioorganique, Université des Sciences et Techniques Montpellier II, Montpellier, France
* Author to whom correspondence should be addressed.
Received: 26 July 2000 / Revised: 21 September 2000 / Accepted: 28 September 2000 / Published: 31 October 2000
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Abstract

The E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassium carbonate in DMF.
Keywords: Acyclonucleoside; Phophonoalkenyl; Michael addition; N-3-alkylation Acyclonucleoside; Phophonoalkenyl; Michael addition; N-3-alkylation
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Rochdi, A.; Taourirte, M.; Lazrek, H.B.; Barascut, J.L.; Imbach, J.L. Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate. Molecules 2000, 5, 1139-1145.

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