Molecules 2000, 5(10), 1139-1145; doi:10.3390/51001139
Article

Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate

A. Rochdi 1 , M. Taourirte 2 , H. B. Lazrek 1,* email, J. L. Barascut 3  and J. L. Imbach 2
1 Laboratoire de Chimie Bioorganique, Faculté des Sciences Semlalia, Marrakech, Marocco 2 Faculté des Sciences et Techniques Gueliz, BP : 618, 40 000, Marrakech, Marocco 3 Laboratoire de Chimie Bioorganique, Université des Sciences et Techniques Montpellier II, Montpellier, France
* Author to whom correspondence should be addressed.
Received: 26 July 2000; in revised form: 21 September 2000 / Accepted: 28 September 2000 / Published: 31 October 2000
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Abstract: The E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassium carbonate in DMF.
Keywords: Acyclonucleoside; Phophonoalkenyl; Michael addition; N-3-alkylation

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MDPI and ACS Style

Rochdi, A.; Taourirte, M.; Lazrek, H.B.; Barascut, J.L.; Imbach, J.L. Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate. Molecules 2000, 5, 1139-1145.

AMA Style

Rochdi A, Taourirte M, Lazrek HB, Barascut JL, Imbach JL. Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate. Molecules. 2000; 5(10):1139-1145.

Chicago/Turabian Style

Rochdi, A.; Taourirte, M.; Lazrek, H. B.; Barascut, J. L.; Imbach, J. L. 2000. "Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate." Molecules 5, no. 10: 1139-1145.

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