Molecules 2000, 5(10), 1139-1145; doi:10.3390/51001139
Article

Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate

1, 2, 1,* email, 3 and 2
Received: 26 July 2000; in revised form: 21 September 2000 / Accepted: 28 September 2000 / Published: 31 October 2000
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The E- and Z- phosphonoalkenyl acyclonucleosides of uracil and thymine were synthesized under Michael addition conditions. Introduction of an alkyl, alkenyl or alkynyl group at the N-3 position of the pyrimidine moiety was accomplished using potassium carbonate in DMF.
Keywords: Acyclonucleoside; Phophonoalkenyl; Michael addition; N-3-alkylation
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MDPI and ACS Style

Rochdi, A.; Taourirte, M.; Lazrek, H.B.; Barascut, J.L.; Imbach, J.L. Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate. Molecules 2000, 5, 1139-1145.

AMA Style

Rochdi A, Taourirte M, Lazrek HB, Barascut JL, Imbach JL. Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate. Molecules. 2000; 5(10):1139-1145.

Chicago/Turabian Style

Rochdi, A.; Taourirte, M.; Lazrek, H. B.; Barascut, J. L.; Imbach, J. L. 2000. "Synthesis of New Bis-Alkylated Phosphono Alkenyl Acyclonucleosides : (Z) and (E)-Diethyl-2-(3-alkyl pyrimidin-1-yl)ethylen-1-yl Phosphonate." Molecules 5, no. 10: 1139-1145.

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