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41 Results Found

  • Article
  • Open Access
34 Citations
5,875 Views
10 Pages

Objective: Numerous studies have proved the importance of Evidence-Based Medicine (EBM) in daily clinical practice, however, clinicians’ attitudes play an important role in determining its implementation. The objective of this study was to inve...

(This article belongs to the Special Issue Medical and Health Professions Education: Are We Stepping Forward?)
  • Review
  • Open Access
333 Citations
52,270 Views
17 Pages

Humans have evolved into what they are today after the passage of 6–7 million years. If we define the beginning of urbanization as the rise of the industrial revolution, less than 0.01% of our species’ history has been spent in modern surroundings. H...

  • Brief Report
  • Open Access
735 Views
1 Page

4 December 2014

Providing optimal care for patients with hemoglobinopathies is common goal for all the health professionals working on the field. The medical community has adopted best practices guidelines to provide similar therapeutic plans. The pre-requisites for...

  • Article
  • Open Access
17 Citations
4,534 Views
14 Pages

Knowledge, Attitude, and Practice of Evidence-Based Medicine among Emergency Doctors in Kelantan, Malaysia

  • Mohd Ghouse Ahmad Ghaus,
  • Tuan Hairulnizam Tuan Kamauzaman and
  • Mohd Noor Norhayati

This study aimed to determine the prevalence of high levels of knowledge, positive attitude, and good practice on evidence-based medicine (EBM) and identify the associated factors for practice score on EBM among emergency medicine doctors in Kelantan...

  • Article
  • Open Access
48 Citations
5,623 Views
12 Pages

Knowledge, Attitude, and Practice towards Evidence-Based Medicine among Northern Saudi Primary Care Physicians: A Cross-Sectional Study

  • Bashayer Farhan ALruwaili,
  • Ashokkumar Thirunavukkarasu,
  • Aseel Awad Alsaidan,
  • Aliyah Muteb AL-Ruwaili and ,
  • Ruqayyah Batel Shati Alanazi,
  • Amal Muhaysin B. Alruwaili,
  • Abdullah Odhayb Alruwaili and
  • Afrah Mohaimeed Altaymani
  • + 3 authors+ 0 author

14 November 2022

The evidence-based practice of primary care physicians is essential because they are the first line of contact with the local community, and they cater to most of their communities’ health needs. In the current study, in which we used a cross-s...

(This article belongs to the Special Issue 2nd Edition of Family Medicine: Opportunities and Challenges for Primary Healthcare)
  • Editorial
  • Open Access
1 Citations
4,815 Views
3 Pages

In the past decades, the scientific quality of biomedical studies has been hierarchically depicted in the well-known pyramid of evidence-based medicine (EBM), with higher and higher levels of evidence moving from the base to the top. Such an approach...

(This article belongs to the Special Issue Plant Innate Immunity 2.0)
  • Review
  • Open Access
8 Citations
9,280 Views
13 Pages

Evidence-Based Medicine: Past, Present, Future

  • Filippos Triposkiadis and
  • Dirk L. Brutsaert

17 July 2025

Early medical traditions include those of ancient Babylonia, China, Egypt, and India. The roots of modern Western medicine, however, go back to ancient Greece. During the Renaissance, physicians increasingly relied on observation and experimentation...

(This article belongs to the Section Clinical Research Methods)
  • Perspective
  • Open Access
63 Citations
22,205 Views
25 Pages

Tinnitus Guidelines and Their Evidence Base

  • Berthold Langguth,
  • Tobias Kleinjung,
  • Winfried Schlee,
  • Sven Vanneste and
  • Dirk De Ridder

24 April 2023

Evidence-based medicine (EBM) is generally accepted as the gold standard for high-quality medicine and, thus, for managing patients with tinnitus. EBM integrates the best available scientific information with clinical experience and patient values to...

(This article belongs to the Section Otolaryngology)
  • Perspective
  • Open Access
10 Citations
10,134 Views
9 Pages

Thirty years after the rise of the evidence-based medicine (EBM) movement, formal training in philosophy remains poorly represented among medical students and their educators. In this paper, I argue that EBM’s reception in this context has resu...

  • Perspective
  • Open Access
6 Citations
5,504 Views
14 Pages

The Evidence-Based Medicine Management of Endometriosis Should Be Updated for the Limitations of Trial Evidence, the Multivariability of Decisions, Collective Experience, Heuristics, and Bayesian Thinking

  • Philippe R. Koninckx,
  • Anastasia Ussia,
  • Assia Stepanian,
  • Ertan Saridogan and ,
  • Mario Malzoni,
  • Charles E. Miller,
  • Jörg Keckstein,
  • Arnaud Wattiez,
  • Geert Page and
  • Leila Adamyan
  • + 7 authors+ 2 authors

3 January 2025

Background/Objectives: The diagnosis and treatment of endometriosis should be based on the best available evidence. Emphasising the risk of bias, the pyramid of evidence has the double-blind, randomised controlled trial and its meta-analyses on top....

(This article belongs to the Section Obstetrics & Gynecology)
  • Perspective
  • Open Access
19 Citations
5,274 Views
11 Pages

29 December 2023

Precision medicine (PM), through the integration of omics and environmental data, aims to provide a more precise prevention, diagnosis, and treatment of disease. Currently, PM is one of the emerging approaches in modern healthcare and public health,...

(This article belongs to the Section Evidence Based Medicine)
  • Review
  • Open Access
2 Citations
3,312 Views
20 Pages

Evidence-Based Medicine and Good Clinical Practice in Research in Pediatric and Adolescent Medicine

  • Ageliki A. Karatza,
  • Asimina Tsintoni,
  • Dimitrios Kapnisis,
  • Despoina Gkentzi and ,
  • Sotirios Fouzas,
  • Eirini Kostopoulou,
  • Xenophon Sinopidis and
  • Nikolaos Antonakopoulos
  • + 3 authors+ 0 author

29 September 2025

Practicing medical research based on the best evidence is gaining increased value and popularity among most medical societies in the current era. Good clinical practice (GCP) is internationally recognized as the scientific and ethical standard for th...

(This article belongs to the Section Pediatric Nursing)
  • Article
  • Open Access
27 Citations
9,874 Views
12 Pages

Applying Evidence-Based Medicine in Telehealth: An Interactive Pattern Recognition Approximation

  • Carlos Fernández-Llatas,
  • Teresa Meneu,
  • Vicente Traver and
  • José-Miguel Benedi

Born in the early nineteen nineties, evidence-based medicine (EBM) is a paradigm intended to promote the integration of biomedical evidence into the physicians daily practice. This paradigm requires the continuous study of diseases to provide the bes...

(This article belongs to the Special Issue Advances in Telehealthcare)
  • Opinion
  • Open Access
2 Citations
1,015 Views
11 Pages

The EU-Joint Clinical Assessment Guidance Documents Fail to Address the Significance of Systematic Literature Reviews and Deviate from the State of the Art

  • Beata Smela,
  • Mondher Toumi,
  • Samuel Aballéa,
  • Steven Simoens and ,
  • Laurent Boyer,
  • Bruno Falissard,
  • Renato Bernardini,
  • Stefano Capri and
  • Pascal Auquier
  • + 4 authors+ 0 author

This paper summarizes an analysis of the Joint Clinical Assessment (JCA) subgroup’s recommendations for systematic literature reviews (SLRs). While the JCA offers clear guidance on study classification, exclusion criteria reporting, and PRISMA...

  • Article
  • Open Access
573 Views
16 Pages

Attitudes and Self-Reported Use of Evidence-Based Medicine Among Physicians in Abha, Saudi Arabia: A Cross-Sectional Study

  • Lama Ali Buhran,
  • Syed Esam Mahmood,
  • Wejdan Fuad Abbag,
  • Abdulrahman Ali Buhran and
  • Razia Aftab Ahmed

Background: Evidence-based medicine (EBM) improves quality by ensuring clinical decisions are based on the latest, most reliable evidence, leading to better patient outcomes, reduced practice variability, and safer care. It fosters continuous learnin...

  • Article
  • Open Access
3 Citations
2,420 Views
14 Pages

A Large Gap in Patients’ Characteristics and Outcomes between the Real-World and Clinical Trial Settings in Community-Acquired Pneumonia and Healthcare-Associated Pneumonia

  • Nobuhiro Asai,
  • Yuichi Shibata,
  • Daisuke Sakanashi,
  • Hideo Kato and ,
  • Mao Hagihara,
  • Yuka Yamagishi,
  • Hiroyuki Suematsu and
  • Hiroshige Mikamo
  • + 3 authors+ 0 author

7 January 2022

(1) Introduction: Evidence-based medicine (EBM) is necessary to standardize treatments for infections because EBM has been established based on the results of clinical trials. Since entry criteria for clinical trials are very strict, it may cause ske...

(This article belongs to the Topic Infectious Diseases)
  • Article
  • Open Access
1,457 Views
19 Pages

6 November 2025

Background: Complementary and alternative medicine (CAM) is increasingly used to supplement evidence-based medicine (EBM), especially in the treatment of cancer patients. Objective: The study aimed to analyze the beliefs, attitudes, and expectations...

(This article belongs to the Special Issue Public Health Prevention Through Integrative Medicine: Community-Based and Society-Level Interventions)
  • Article
  • Open Access
4 Citations
9,292 Views
15 Pages

A Journey Through Philosophy and Medicine: From Aristotle to Evidence-Based Decisions

  • José Nunes de Alencar,
  • Marcio Henrique de Jesus Oliveira,
  • Maria Catarina Nunes Sampaio,
  • Maria Francisca Rego and
  • Rui Nunes

The evolution of medical reasoning is deeply intertwined with philosophical thought, beginning with Aristotle’s foundational work in deductive logic. Aristotle’s principles significantly influenced early medical practice, shaping the work...

  • Article
  • Open Access
14 Citations
5,985 Views
10 Pages

10 July 2024

Background/Objectives: Evidence-based medicine (EBM) shapes most clinical guidelines. Although the advent of EBM marked a significant advancement, failure to include sex differences in the study design and analysis of most trials leads to an under-re...

(This article belongs to the Section Clinical Guidelines)
  • Review
  • Open Access
112 Citations
16,565 Views
20 Pages

Translational Research in the Era of Precision Medicine: Where We Are and Where We Will Go

  • Ruggero De Maria Marchiano,
  • Gabriele Di Sante,
  • Geny Piro,
  • Carmine Carbone and ,
  • Giampaolo Tortora,
  • Luca Boldrini,
  • Antonella Pietragalla,
  • Gennaro Daniele,
  • Maria Tredicine and
  • Giovanni Scambia
  • + 10 authors+ 5 authors

18 March 2021

The advent of Precision Medicine has globally revolutionized the approach of translational research suggesting a patient-centric vision with therapeutic choices driven by the identification of specific predictive biomarkers of response to avoid ineff...

(This article belongs to the Special Issue Personalized Medicine and Multidisciplinary Approach in a Clinical Research Hospital)
  • Article
  • Open Access
29 Citations
16,443 Views
19 Pages

Italian Expert Consensus on Clinical and Therapeutic Management of Multiple Chemical Sensitivity (MCS)

  • Giovanni Damiani,
  • Marco Alessandrini,
  • Daniela Caccamo,
  • Andrea Cormano and ,
  • Gianpaolo Guzzi,
  • Andrea Mazzatenta,
  • Alessandro Micarelli,
  • Alberto Migliore,
  • Alba Piroli and
  • Paolo Daniele Maria Pigatto
  • + 7 authors+ 2 authors

Multiple chemical sensitivity (MCS) is a multisystem, recurrent, environmental disorder that flares in response to different exposures (i.e., pesticides, solvents, toxic metals and molds) under the threshold limit value (TLV) calculated for age and g...

  • Article
  • Open Access
14 Citations
3,123 Views
18 Pages

Microbiome in Lower Urinary Tract Symptoms (LUTSs): Mapping the State of the Art with Bibliometric Analysis

  • Hadi Mostafaei,
  • Hanieh Salehi-Pourmehr,
  • Mohammad Sajjad Rahnama’i,
  • Helia Mostafaei and ,
  • Shahrokh F. Shariat and
  • Sakineh Hajebrahimi
  • + 1 author+ 0 author

16 February 2023

Background: The main objective of this study is to provide the first characterization of the current research field of the clinical microbiome in LUTSs. Methods: First-of-its-kind scientometric insight into the historical development and structural s...

(This article belongs to the Special Issue Urinary Microbiome and Genitourinary System Disorders)
  • Review
  • Open Access
18 Citations
5,347 Views
42 Pages

Survey on the Biomedical Text Summarization Techniques with an Emphasis on Databases, Techniques, Semantic Approaches, Classification Techniques, and Similarity Measures

  • Dipti Pawar,
  • Shraddha Phansalkar,
  • Abhishek Sharma,
  • Gouri Kumar Sahu and ,
  • Chun Kit Ang and
  • Wei Hong Lim
  • + 1 author+ 0 author

26 February 2023

Biomedical text summarization (BTS) is proving to be an emerging area of work and research with the need for sustainable healthcare applications such as evidence-based medicine practice (EBM) and telemedicine which help effectively support healthcare...

  • Article
  • Open Access
7 Citations
2,887 Views
20 Pages

Explainable Boosting Machines Identify Key Metabolomic Biomarkers in Rheumatoid Arthritis

  • Fatma Hilal Yagin,
  • Cemil Colak,
  • Abdulmohsen Algarni,
  • Ali Algarni and ,
  • Fahaid Al-Hashem and
  • Luca Paolo Ardigò
  • + 1 author+ 0 author

30 April 2025

Background and Objectives: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by joint inflammation and pain. Metabolomics approaches, which are high-throughput profiling of small molecule metabolites in plasma or serum in RA pat...

(This article belongs to the Special Issue New Strategies for the Diagnosis and Treatment of Rheumatic and Musculoskeletal Diseases)
  • Systematic Review
  • Open Access
19 Citations
10,011 Views
19 Pages

Photobiomodulation and Growth Factors in Dentistry: A Systematic Review

  • Gianna Dipalma,
  • Angelo Michele Inchingolo,
  • Assunta Patano,
  • Irene Palumbo and ,
  • Mariafrancesca Guglielmo,
  • Irma Trilli,
  • Anna Netti,
  • Irene Ferrara,
  • Fabio Viapiano and
  • Luisa Limongelli
  • + 10 authors+ 5 authors

29 September 2023

Photobiomodulation, or Low-Level Laser Therapy, is a therapeutic technique that can be applied in tissue regenerative surgery. By stimulating the cellular compartment, photobiomodulation promotes cell proliferation, enabling tissue restoration after...

  • Article
  • Open Access
8 Citations
2,711 Views
9 Pages

A Gap of Patients with Infective Endocarditis between Clinical Trials and the Real World

  • Nobuhiro Asai,
  • Yuichi Shibata,
  • Jun Hirai,
  • Wataru Ohashi and ,
  • Daisuke Sakanashi,
  • Hideo Kato,
  • Mao Hagihara,
  • Hiroyuki Suematsu and
  • Hiroshige Mikamo
  • + 4 authors+ 0 author

16 February 2023

Introduction: A randomized control trial (RCT) is considered to be the highest level in the Evidence-Based Medicine (EBM) pyramid. While EBM is essential to make a practical tool such as a prognostic guideline, it has been unclear how many patients i...

(This article belongs to the Special Issue Infective Endocarditis: What Is New in the Clinical Research?)
  • Article
  • Open Access
6 Citations
3,417 Views
12 Pages

Clinicians’ Perceived Understanding of Biostatistical Results in the Medical Literature: A Cross-Sectional Study

  • Kurubaran Ganasegeran,
  • Alan Swee Hock Ch’ng,
  • Mohd Fadzly Amar Jamil and
  • Irene Looi

Background and objectives: The continuum of evidence-based medicine (EBM) depends solely on clinicians’ commitment to keep current with the latest clinical information. Exploration on clinicians’ understanding of biostatistical results in...

  • Article
  • Open Access
14 Citations
4,867 Views
16 Pages

Probable Pain on the Pain Assessment in Impaired Cognition (PAIC15) Instrument: Assessing Sensitivity and Specificity of Cut-Offs against Three Standards

  • Jenny T. van der Steen,
  • Andrew Westzaan,
  • Kimberley Hanemaayer,
  • Muhamad Muhamad and ,
  • Margot W. M. de Waal and
  • Wilco P. Achterberg
  • + 1 author+ 0 author

Observational pain scales can help to identify pain in persons with dementia who may have difficulty expressing pain verbally. The Pain Assessment in Impaired Cognition-15 (PAIC15) covers 15 items that indicate pain, but it is unclear how probable pa...

(This article belongs to the Special Issue Pain Assessment in Impaired Cognition)
  • Article
  • Open Access
1 Citations
1,278 Views
13 Pages

Evidence-based medicine (EBM) supplies the best available data, yet clinicians still face low-value care, surrogate-driven reversals, and pseudoscientific claims. We propose Semi-Imperative Evidentialism (SIE), a normative framework that links eviden...

(This article belongs to the Special Issue Clinical Ethics and Philosophy)
  • Case Report
  • Open Access
14 Citations
10,511 Views
13 Pages

5 November 2023

The use of natural compounds and, in general, the use of Complementary and Alternative Medicine (CAM), is growing steadily worldwide, both due to commercial pressure and the increasing use of self-medication and the desire to manage one’s own p...

(This article belongs to the Special Issue Evolution of Cancer Pharmacological Treatment: Natural Compounds as Adjuvants for Cancer Treatments)
  • Article
  • Open Access
6 Citations
4,225 Views
15 Pages

A Decision Support System with Artificial Intelligence and Natural Language Processing to Mitigate the Deduction Rate of Health Insurance Claims

  • Shey-Chiang Su,
  • Chun-Che Huang,
  • Roger R. Gung,
  • Li-Kai Hsiung and ,
  • Zhi-Wei Gao and
  • Cheng-En Tsai
  • + 1 author+ 0 author

7 December 2021

Globally, 20% to 40% of medical resources are wasted, which could be avoided through professional audit of health insurance claims. The professional audit can pinpoint excessive use of unnecessary medicines and medical examinations. Taiwan’s Na...

(This article belongs to the Special Issue Emerging Industry – Promoting Human Performance and Health)
  • Article
  • Open Access
5 Citations
2,151 Views
19 Pages

Curcumin-Functionalized Ag and ZnO Nanoparticles: A Nanotherapeutic Approach for Treating Infections in Diabetic Wounds

  • Mahboubeh Dolatyari,
  • Parisa Rostami,
  • Mahya Rostami,
  • Ali Rostami and
  • Hamit Mirtagioglu

Chronic wounds, such as diabetic ulcers, remain a significant clinical challenge due to high infection risk and delayed healing. This study presents a comprehensive evaluation of a novel wound dressing incorporating curcumin-functionalized silver&nda...

(This article belongs to the Special Issue Emerging Nanomaterials and Nanotechnologies for Biomedical and Related Applications)
  • Article
  • Open Access
13 Citations
6,062 Views
25 Pages

29 April 2022

(1) Background: The purpose of this article is to review pharmacological treatments for COVID-19 (currently approved by the EMA (European Medical Agency) and FDA (Food and Drug Administration)) and highlight their potential audio-vestibular side-effe...

(This article belongs to the Special Issue Audio-Vestibular Disorders in the COVID-19 Pandemics)
  • Review
  • Open Access
44 Citations
12,148 Views
14 Pages

27 March 2022

Plant-based diets are becoming increasingly popular. Vegetarian diets are better for the environment and exhibit health benefits. A correctly balanced plant-based diet is appropriate at every stage of life. Compared to omnivores, vegetarians consume...

(This article belongs to the Special Issue Impact of Diet Composition on Insulin Resistance)
  • Article
  • Open Access
3 Citations
2,182 Views
12 Pages

Is It Still Time for Safety Walkaround? Pilot Project Proposing a New Model and a Review of the Methodology

  • Michela Ferrara,
  • Natascha Pascale,
  • Mauro Ciavarella,
  • Giuseppe Bertozzi and ,
  • Angela Pia Bellettieri and
  • Aldo Di Fazio
  • + 1 author+ 0 author

Background and Objectives: Healthcare facilities are complex systems due to the interaction between different factors (human, environmental, management, and technological). As complexity increases, it is known that the possibility of error increases;...

(This article belongs to the Section Epidemiology & Public Health)
  • Systematic Review
  • Open Access
3 Citations
16,121 Views
9 Pages

Diclofenac Sodium for Fever Control in Neurocritical Care: A Systematic Review

  • Tommaso Rochat Negro,
  • Michael Watchi,
  • Hannah Wozniak,
  • Jerome Pugin and
  • Herve Quintard

13 May 2023

Background: Fever is extremely common in neurocritical care patients and is independently associated with a worse outcome. Non-steroidal anti-inflammatory drugs (NSAIDs) lower the hypothalamic set point temperature through the inhibition of prostagla...

(This article belongs to the Section Intensive Care)
  • Review
  • Open Access
6 Citations
5,599 Views
19 Pages

A Historical Analysis of Randomized Controlled Trials in Rotator Cuff Tears

  • Vincenzo Candela,
  • Umile Giuseppe Longo,
  • Calogero Di Naro,
  • Gabriella Facchinetti and ,
  • Anna Marchetti,
  • Gaia Sciotti,
  • Giulia Santamaria,
  • Ilaria Piergentili,
  • Maria Grazia De Marinis and
  • Vincenzo Denaro
  • + 6 authors+ 1 author

Background and objectives: Our research aimed to evaluate the quality of reporting of randomized controlled trials (RCTs) linked to rotator cuff (RC) tears. The present study analyzed factors connected to the quality of the RCTs and trends in the qua...

  • Article
  • Open Access
638 Views
14 Pages

Awareness, Attitudes, and Behavioral Practices of the Population of the Republic of Kazakhstan Regarding Tuberculosis

  • Nadira Aitambayeva,
  • Altyn Aringazina,
  • Temur Yeshmuratov,
  • Laila Nazarova and ,
  • Bekdaulet Akimniyazova,
  • Tatyana Popova,
  • Sholpan Aliyeva,
  • Akmaral Savkhatova,
  • Nazerke Narymbayeva and
  • Akylbek Saktapov
  • + 6 authors+ 1 author

Background: This study aims to examine the level of awareness, attitudes (including stigma and discrimination), and behaviors related to tuberculosis among the population of the Republic of Kazakhstan to identify priorities for raising awareness and...

  • Systematic Review
  • Open Access
3 Citations
1,314 Views
23 Pages

Temporal and Contextual Variations in Job Satisfaction Between Physicians and Nurses: A Systematic Review and Meta-Analysis

  • Nazerke Narymbayeva,
  • Maksut Kamaliev,
  • Konrad Tomasz Juszkiewicz,
  • Kuralay Kanafyanova and ,
  • Sholpan Aliyeva,
  • Nadira Aitambayeva,
  • Laila Nazarova,
  • Sharapat Moiynbayeva,
  • Akylbek Saktapov and
  • Shnara Svetlanova
  • + 5 authors+ 0 author

21 November 2025

Objectives: This systematic review and meta-analysis evaluated differences in job satisfaction scores between nurses and physicians, examining variation by (a) care setting (hospital, emergency department, outpatient, mixed), and (b) time period (pre...

(This article belongs to the Special Issue Innovating Care in the Post-Pandemic Era: Models, Leadership, and Technologies for the Future of Nursing)
  • Review
  • Open Access
786 Views
28 Pages

Exploring the Role of Long Non-Coding RNAs in Mediating Cisplatin Resistance in Glioma/Glioblastoma Cells

  • Hadi Sahrai,
  • Reza Mosaddeghi-Heris,
  • Nasrin Forghani,
  • Ali Norouzi and ,
  • Sahand Zare,
  • Hamed Aghazadeh,
  • Kimia Bagheri,
  • Rebecca Kocsis,
  • Firoz Ahmed and
  • Maryam Farzaneh
  • + 7 authors+ 2 authors

Malignant gliomas are highly aggressive primary brain tumors for which the therapeutic efficacy of cisplatin is frequently limited by intrinsic or acquired drug resistance. Despite advances in adjuvant therapies, overcoming chemoresistance remains a...

(This article belongs to the Special Issue The Role of RNAs in Cancers: Recent Advances)
  • Article
  • Open Access
24 Citations
4,899 Views
12 Pages

The Influence of Prebiotics on Wheat Flour, Dough, and Bread Properties; Resistant Starch, Polydextrose, and Inulin

  • Fereshteh Ansari,
  • Tatiana Colombo Pimentel,
  • Hadi Pourjafar,
  • Salam A. Ibrahim and
  • Seid Mahdi Jafari

26 October 2022

The addition of prebiotics to bread is one of the most important ways to improve its techno-functional properties. In this study, the effects of resistant starch, polydextrose, and inulin on wheat flour, dough, and bread properties were investigated....

(This article belongs to the Section Grain)