Special Issue "Recent Progress in EBV Research"

Guest Editor
Prof. Dr. Eric C. Johannsen
Assistant Professor, Morgridge Institute for Research, University of Wisconsin, 330 N. Orchard St., Room 3268, Madison, WI 53717, USA
Website: http://www2.medicine.wisc.edu/home/people-search/people/staff/1118/Johannsen_Eric/
E-Mail: ejohannsen@medicine.wisc.edu
Phone: +608 316 4423

Submission

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• Epstein-Barr Virus
• EBV
• viral oncogenesis
• herpesvirus
• gammaherpesvirus
• viral latency
• growth transformation
• replication
• lymphoma
• burkitt lymphoma
• hodgkin lymphoma
• lymphoproliferative disease nasopharyngeal carcinoma
• gastric carcinoma
• infectious mononucleosis

Type of Paper: Review
Title: The Latent Membrane Protein 1 in EBV Associated Disease
Authors: Asif Qureshi and Joanna B. Wilson
Affiliation: University of Glasgow, Glasgow, UK
Abstract: The latent membrane protein 1 (LMP1) is regarded as the primary onco-protein encoded by Epstein-Barr virus. LMP1 appears to play an important role in the development of EBV-associated nasopharyngeal carcinoma and Hodgkin's lymphoma and possibly several other EBV-associated disorders, including certain autoimmune diseases. The gene displays classic oncogene activity in cell culture transfection assays, however its expression in vivo has revealed the complexity of its actions, inducing proliferation, angiogenesis, oxidative stress and inflammation. In this review we summarise findings made using transgenic mouse models to explore the role of LMP1 in vivo, both in epithelial cells and B-cells. We discuss how these observations relate to LMP1 function in the virus and its role in EBV associated disease.

Type of Paper: Article
Title: Epstein-Barr Virus (EBV)-infected and EBV free Nasopharyngeal Carcinoma
Author: Chin-Tarng Lin
Affiliation: Postgraduate Institute and Department of Pathology, College of Medicine, National Taiwan University and Hospital,Taipei,10002,Taiwan; Address：#7 Chung-Shan South Road, Taipei 100, Taiwan; Dept of Pathology, National Taiwan University Hospital; E-MAILL：ctl@ntu.edu.tw; Tel.：886-2-23123456 Ext 67606; Fax：886-2-2382-6649.
Abstract: Nasopharyngeal carcinoma (NPC) is one of the common cancers among Chinese living in South China, Taiwan, Singapore and several other countries or indistinct regions. The etiological factors have not been clearly identified yet. So far, no any major gene related with hereditary factor has been identified in NPC carcinogenesis; however, some environmental factors, such as consumption of salted fish and Chinese herbs and long term exposure to the sulfuric acid vapor have been tentatively linked to NPC induction, while research has proposed that there is a close association between Epstein-Barr virus (EBV) and NPC pathogenesis. To investigate the relationship between EBV and NPC, we have established ten NPC cell lines. After extensive investigation, we conclude that EBV establish an infection only in nasopharyngeal neoplastic cells, but not in nasopharyngeal metaplastic epithelial cells, through the IgA receptor (secretory component protein)-mediated endocytosis. Furthermore, using the in vitro and in vivo systems to analyze the response of NPC host genes to EBV infection, we found that EBV cannot turn on any host gene which is not expressed in NPC cells, but can enhance the gene expression in tumor cells which express this gene. These investigations indicate that EBV play an important role in enhancement of NPC progression, but is involved in neither the initiation nor the promotion of NPC pathogenesis. This is of fundamental importance to our concept of the EBV-associated NPC pathogenesis and may provide basis for another research direction to investigate NPC carcinogenesis.