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Viruses 2013, 5(6), 1587-1606; doi:10.3390/v5061587
Review

NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1

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Received: 28 May 2013; in revised form: 17 June 2013 / Accepted: 18 June 2013 / Published: 21 June 2013
(This article belongs to the Special Issue Recent Progress in EBV Research)
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Abstract: The principal Epstein-Barr virus (EBV) oncoprotein, Latent Membrane Protein 1 (LMP1), is expressed in most EBV-associated human malignancies. LMP1 mimics CD40 receptor signaling to provide infected cells with constitutive NF-κB, MAP kinase, IRF7, and PI3 kinase pathway stimulation. EBV-transformed B-cells are particularly dependent on constitutive NF-κB activity, and rapidly undergo apoptosis upon NF-κB blockade. Here, we review LMP1 function, with special attention to current understanding of the molecular mechanisms of LMP1-mediated NF-κB and IRF7 pathway activation. Recent advances include the elucidation of transmembrane motifs important for LMP1 trafficking and ligand-independent signaling, analysis of genome-wide LMP1 gene targets, and the identification of novel cell proteins that mediate LMP1 NF-κB and IRF7 pathway activation.
Keywords: herpesvirus; apoptosis; cancer; innate immunity; transformation; integral membrane protein; signal transduction; proliferation; ubiquitin; lymphoma; oncogene herpesvirus; apoptosis; cancer; innate immunity; transformation; integral membrane protein; signal transduction; proliferation; ubiquitin; lymphoma; oncogene
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Ersing, I.; Bernhardt, K.; Gewurz, B.E. NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1. Viruses 2013, 5, 1587-1606.

AMA Style

Ersing I, Bernhardt K, Gewurz BE. NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1. Viruses. 2013; 5(6):1587-1606.

Chicago/Turabian Style

Ersing, Ina; Bernhardt, Katharina; Gewurz, Benjamin E. 2013. "NF-κB and IRF7 Pathway Activation by Epstein-Barr Virus Latent Membrane Protein 1." Viruses 5, no. 6: 1587-1606.



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