Next Article in Journal
Arenavirus Variations Due to Host-Specific Adaptation
Next Article in Special Issue
Interpreting the Epstein-Barr Virus (EBV) Epigenome Using High-Throughput Data
Previous Article in Journal
Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein
Previous Article in Special Issue
Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis—Association and Causation
Viruses 2013, 5(1), 226-240; doi:10.3390/v5010226
Review

Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus

 and
*
Received: 5 December 2012 / Revised: 23 December 2012 / Accepted: 11 January 2013 / Published: 16 January 2013
(This article belongs to the Special Issue Recent Progress in EBV Research)
View Full-Text   |   Download PDF [260 KB, uploaded 12 May 2015]   |   Browse Figure

Abstract

Epstein-Barr Nuclear Antigen 1 (EBNA1) is a multifunctional protein encoded by EBV. EBNA1’s role in maintaining EBV in latently proliferating cells, by mediating EBV genome synthesis and nonrandom partitioning to daughter cells, as well as regulating viral gene transcription, is well characterized. Less understood are the roles of EBNA1 in affecting the host cell to provide selective advantages to those cells that harbor EBV. In this review we will focus on the interactions between EBNA1 and the host cell that may provide EBV-infected cells selective advantages beyond the maintenance of EBV.
Keywords: Epstein Barr Virus; Epstein Barr Virus nuclear antigen one; human tumor virus; cancer Epstein Barr Virus; Epstein Barr Virus nuclear antigen one; human tumor virus; cancer
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Smith, D.W.; Sugden, B. Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus. Viruses 2013, 5, 226-240.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert