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• Sugden, B
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Viruses 2013, 5(1), 226-240; doi:10.3390/v5010226

Review

Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr Virus

Danielle Westhoff Smith and Bill Sugden*

Department of Oncology, McArdle Laboratory for Cancer Research, Madison, WI 53706, USA

* Author to whom correspondence should be addressed.

Received: 5 December 2012; in revised form: 23 December 2012 / Accepted: 11 January 2013 / Published: 16 January 2013

(This article belongs to the Special Issue Recent Progress in EBV Research)

Download PDF Full-Text [260 KB, uploaded 16 January 2013 14:57 CET]

Abstract: Epstein-Barr Nuclear Antigen 1 (EBNA1) is a multifunctional protein encoded by EBV. EBNA1’s role in maintaining EBV in latently proliferating cells, by mediating EBV genome synthesis and nonrandom partitioning to daughter cells, as well as regulating viral gene transcription, is well characterized. Less understood are the roles of EBNA1 in affecting the host cell to provide selective advantages to those cells that harbor EBV. In this review we will focus on the interactions between EBNA1 and the host cell that may provide EBV-infected cells selective advantages beyond the maintenance of EBV.

Keywords: Epstein Barr Virus; Epstein Barr Virus nuclear antigen one; human tumor virus; cancer

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