Special Issue "Perspectives and Challenges in Coronavirus Research"
A special issue of Viruses (ISSN 1999-4915).
Deadline for manuscript submissions: closed (31 January 2013)
Dr. Sonia Navas-Martin
Assistant Professor, Dept. of Microbiology & Immunology, Member, Center for Molecular Virology & Translational Neuroscience, Member, Institute for Molecular Medicine & Infectious Disease, Drexel University College of Medicine, 245 N. 15th Street, NCB Room 18309 MS1013A, Philadelphia, PA 19102 USA
Phone: +215 762 7284
Fax: +215 762 8284
Coronaviruses (CoVs) are the most complex positive-sense single-stranded RNA (ssRNA+) viruses and cause acute self-limited and often fatal diseases in animals including humans. Since their discovery more than 50 years ago, some CoVs have been studied because of their veterinary relevance; other CoVs are considered useful models for human diseases such as neuroinflammation, multiple sclerosis, and hepatitis. Human CoVs are associated with mild respiratory tract disease and cause 30% of common cold in season. Just a decade ago a novel CoV was identified as the etiological agent of Severe Acute Respiratory Syndrome (SARS), the first pandemic of the 21st century. The identification of SARS-CoV has been a driver for the surge in CoV research in recent years. This special issue will contain reviews and original research papers on CoVs cross-species transmission, virus entry, replication and assembly, virus-host interactions, innate and adaptative immunity, pathogenesis, antivirals, vaccines and newly identified CoVs. We hope in this issue to capture the scope of these exciting developments and to provide perspectives and challenges in CoV research.
Dr. Sonia Navas-Martin
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed Open Access monthly journal published by MDPI.
- innate immunity
- virulence factor
- chronic demyelination
- cytokine storm
Article: Comparative Genomics of Korean Infectious Bronchitis Viruses (IBVs) and an Animal Model to Evaluate Pathogenicity of IBVs to the Reproductive Organs
Viruses 2012, 4(11), 2670-2683; doi:10.3390/v4112670
Received: 23 August 2012; in revised form: 18 October 2012 / Accepted: 18 October 2012 / Published: 30 October 2012| Download PDF Full-text (676 KB) | Download XML Full-text
Review: The Role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus Pathogenesis
Viruses 2012, 4(11), 2902-2923; doi:10.3390/v4112902
Received: 1 October 2012; in revised form: 2 November 2012 / Accepted: 5 November 2012 / Published: 7 November 2012| Download PDF Full-text (465 KB) | Download XML Full-text
Review: Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic Strategies
Viruses 2012, 4(11), 3044-3068; doi:10.3390/v4113044
Received: 5 October 2012; in revised form: 31 October 2012 / Accepted: 2 November 2012 / Published: 12 November 2012| Download PDF Full-text (438 KB) | Download XML Full-text
Article: Virus Pathogen Database and Analysis Resource (ViPR): A Comprehensive Bioinformatics Database and Analysis Resource for the Coronavirus Research Community
Viruses 2012, 4(11), 3209-3226; doi:10.3390/v4113209
Received: 2 October 2012; in revised form: 13 November 2012 / Accepted: 14 November 2012 / Published: 19 November 2012| Download PDF Full-text (1534 KB) | Download XML Full-text |
Viruses 2012, 4(11), 3245-3269; doi:10.3390/v4113245
Received: 21 October 2012; in revised form: 14 November 2012 / Accepted: 15 November 2012 / Published: 21 November 2012| Download PDF Full-text (890 KB) | Download XML Full-text
Viruses 2012, 4(12), 3440-3451; doi:10.3390/v4123440
Received: 27 September 2012; in revised form: 26 November 2012 / Accepted: 27 November 2012 / Published: 30 November 2012| Download PDF Full-text (600 KB) | Download XML Full-text
Article: Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E
Viruses 2012, 4(12), 3689-3700; doi:10.3390/v4123689
Received: 11 October 2012; in revised form: 13 November 2012 / Accepted: 23 November 2012 / Published: 12 December 2012| Download PDF Full-text (611 KB) | Download XML Full-text |
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: Innate Immune evasion of murine Coronaviruses and SARS-CoV and its Implications in Pathogenesis
Authors: Sonia Navas-Martin 1,2* and Renzo Perales-Linares1,2
Affiliation: 1Department of Microbiology and Immunology, 2 Center for Molecular Virology and Translational Neuroscience, Institute for Molecular Medicine and Infectious Disease, Drexel University College of Medicine, 245 North 15th Street, Philadelphia, PA 19102, USA
E-Mails: firstname.lastname@example.org (S.N.M.); email@example.com (R.P.L.)
* Author to whom correspondence should be addressed; Tel: +1 215 762 7284, Fax: + 1 215 762 8284,firstname.lastname@example.org
Abstract: How coronaviruses are sensed by the innate immune response, and in particular, by pattern recognition receptors (PRRs) remains poorly characterized. Recently, a few PRRs that sense murine coronaviruses and Severe Acute Respiratory Syndrome CoV (SARS) in a cell-type dependent manner have been identified, although its role in pathogenesis remains to be defined. In addition, emerging evidence suggest that coronaviruses have evolved evasion and countermeasures mechanisms to antagonize the innate immune response. Here we review our current understanding of the molecular mechanisms of coronavirus evasion and counteraction of the innate immune response, and discuss its implications in pathogenesis focusing in murine coronaviruses and SARS.
Keywords: coronavirus, viral countermeasure, SARS, pattern recognition receptors, innate immune evasion, IFN, TLR
Last update: 28 January 2013