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Involvement of Autophagy in Coronavirus Replication
Avian Viral Diseases, The Pirbright Institute, Compton Laboratory, High Street, Compton, Newbury, Berkshire, RG20 7NN, UK
* Authors to whom correspondence should be addressed.
Received: 27 September 2012; in revised form: 26 November 2012 / Accepted: 27 November 2012 / Published: 30 November 2012
Abstract: Coronaviruses are single stranded, positive sense RNA viruses, which induce the rearrangement of cellular membranes upon infection of a host cell. This provides the virus with a platform for the assembly of viral replication complexes, improving efficiency of RNA synthesis. The membranes observed in coronavirus infected cells include double membrane vesicles. By nature of their double membrane, these vesicles resemble cellular autophagosomes, generated during the cellular autophagy pathway. In addition, coronavirus infection has been demonstrated to induce autophagy. Here we review current knowledge of coronavirus induced membrane rearrangements and the involvement of autophagy or autophagy protein microtubule associated protein 1B light chain 3 (LC3) in coronavirus replication.
Keywords: coronavirus; IBV; autophagy; double membrane vesicles; replication-transcription complexes
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Cite This Article
MDPI and ACS Style
Maier, H.J.; Britton, P. Involvement of Autophagy in Coronavirus Replication. Viruses 2012, 4, 3440-3451.
Maier HJ, Britton P. Involvement of Autophagy in Coronavirus Replication. Viruses. 2012; 4(12):3440-3451.
Maier, Helena J.; Britton, Paul. 2012. "Involvement of Autophagy in Coronavirus Replication." Viruses 4, no. 12: 3440-3451.