Special Issue "Ricin Toxin"

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A special issue of Toxins (ISSN 2072-6651).

Deadline for manuscript submissions: closed (31 July 2011)

Special Issue Editors

Guest Editor
Prof. Dr. Bruce Magun
Department of Cell and Developmental Biology, Oregon Health and Science University, 3181 S.W. Sam Jackson Park Rd., Portland, OR 97239, USA
Website: http://www.ohsu.edu/cellbio/faculty/faculty%20pages/magunb.html
E-Mail: magunb@ohsu.edu
Phone: +1 503 494 5824
Fax: +1 503 494 4253

Guest Editor
Prof. Dr. Jon D. Robertus
Department of Chemistry and Biochemistry, 1 University Station A5300, University of Texas, Austin, TX 78712, USA
Website: http://robertus.cm.utexas.edu/
E-Mail: jrobertus@mail.utexas.edu

Special Issue Information

Dear Colleagues,

The toxicity of castor plant seeds has been known since antiquity; today we are aware that the toxic agent is a heterodimeric protein toxin called ricin. The exquisite potency of this protein has been of great interest to the general public. Ricin was used by the KGB to assassinate the dissident Georgi Markov in the famous “umbrella tip” incident; this story has featured in many news stories, documentaries, and several fictional adaptations. The scientific community shares this fascination with ricin. What is the secret behind its unusual potency, what biology can we learn from its analysis, can we use ricin as a tool for our benefit? Scientific investigation of ricin encompasses many sub disciplines. These include structural and mechanistic investigations of an enzyme that has evolved to catalytic perfection in its depurination of host ribosomes. The toxin subverts cell uptake and internal trafficking mechanisms to reach the cytoplasm and its investigation has shed light on those fields of research. Because of its ease of purification and toxicity, ricin has been implicated as a terrorist weapon. This has led to work on vaccines and chemical antidotes. There has also been interest in harnessing ricin to generate target specific toxins, particularly against tumor lines. Ricin has also stimulated basic research to understand the exact nature of its induction of morbidity and mortality. In this issue of Toxins we present contemporary work on this intriguing, multifaceted toxin.

Prof. Dr. Bruce Magun
Prof. Dr. Jon D. Robertus
Guest Editors

Keywords

  • ricin
  • drug design
  • cell trafficking
  • bioterrorism

Published Papers (11 papers)

by , ,  and
Toxins 2012, 4(1), 15-27; doi:10.3390/toxins4010015
Received: 23 November 2011; in revised form: 22 December 2011 / Accepted: 23 December 2011 / Published: 6 January 2012
Show/Hide Abstract | Cited by 8 | PDF Full-text (656 KB) | HTML Full-text | XML Full-text

by , , , , , , , , ,  and
Toxins 2011, 3(11), 1405-1419; doi:10.3390/toxins3111405
Received: 2 September 2011; in revised form: 23 October 2011 / Accepted: 1 November 2011 / Published: 11 November 2011
Show/Hide Abstract | Cited by 5 | PDF Full-text (490 KB) | HTML Full-text | XML Full-text | Supplementary Files

by
Toxins 2011, 3(11), 1373-1392; doi:10.3390/toxins3111373
Received: 12 August 2011; in revised form: 13 October 2011 / Accepted: 14 October 2011 / Published: 4 November 2011
Show/Hide Abstract | Cited by 9 | PDF Full-text (219 KB) | HTML Full-text | XML Full-text

by , , , , ,  and
Toxins 2011, 3(10), 1332-1372; doi:10.3390/toxins3101332
Received: 15 August 2011; in revised form: 26 September 2011 / Accepted: 30 September 2011 / Published: 24 October 2011
Show/Hide Abstract | Cited by 10 | PDF Full-text (5690 KB) | HTML Full-text | XML Full-text

by , ,  and
Toxins 2011, 3(10), 1233-1248; doi:10.3390/toxins3101233
Received: 11 August 2011; in revised form: 21 September 2011 / Accepted: 26 September 2011 / Published: 13 October 2011
Show/Hide Abstract | Cited by 4 | PDF Full-text (3329 KB) | HTML Full-text | XML Full-text

by , ,  and
Toxins 2011, 3(9), 1203-1219; doi:10.3390/toxins3091203
Received: 1 July 2011; in revised form: 25 August 2011 / Accepted: 16 September 2011 / Published: 23 September 2011
Show/Hide Abstract | Cited by 2 | PDF Full-text (1972 KB) | HTML Full-text | XML Full-text | Supplementary Files

by , , ,  and
Toxins 2011, 3(9), 1163-1184; doi:10.3390/toxins3091163
Received: 18 July 2011; in revised form: 17 August 2011 / Accepted: 5 September 2011 / Published: 15 September 2011
Show/Hide Abstract | Cited by 4 | PDF Full-text (804 KB) | HTML Full-text | XML Full-text

by , , ,  and
Toxins 2011, 3(9), 1131-1145; doi:10.3390/toxins3091131
Received: 27 July 2011; in revised form: 26 August 2011 / Accepted: 30 August 2011 / Published: 9 September 2011
Show/Hide Abstract | Cited by 1 | PDF Full-text (426 KB) | HTML Full-text | XML Full-text

by  and
Toxins 2011, 3(7), 834-847; doi:10.3390/toxins3070834
Received: 7 June 2011; in revised form: 7 June 2011 / Accepted: 28 June 2011 / Published: 5 July 2011
Show/Hide Abstract | PDF Full-text (708 KB) | HTML Full-text | XML Full-text

by  and
Toxins 2011, 3(7), 787-801; doi:10.3390/toxins3070787
Received: 18 May 2011; in revised form: 21 June 2011 / Accepted: 23 June 2011 / Published: 30 June 2011
Show/Hide Abstract | Cited by 9 | PDF Full-text (414 KB) | HTML Full-text | XML Full-text

by
Toxins 2011, 3(4), 398-408; doi:10.3390/toxins3040398
Received: 16 March 2011; in revised form: 31 March 2011 / Accepted: 31 March 2011 / Published: 4 April 2011
Show/Hide Abstract | Cited by 7 | PDF Full-text (183 KB) | HTML Full-text | XML Full-text

Last update: 5 March 2014

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