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Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin
Division of Infectious Disease, Wadsworth Center, New York State Department of Health, Albany, NY 12208, USA
Department of Biomedical Sciences, University at Albany School of Public Health, Albany, NY 12201, USA
* Author to whom correspondence should be addressed.
Received: 27 July 2011; in revised form: 26 August 2011 / Accepted: 30 August 2011 / Published: 9 September 2011
(This article belongs to the Special Issue Ricin Toxin
Abstract: The entry of ricin toxin into macrophages and certain other cell types in the spleen and liver results in toxin-induced inflammation, tissue damage and organ failure. It has been proposed that uptake of ricin into macrophages is facilitated by the mannose receptor (MR; CD206), a C-type lectin known to recognize the oligosaccharide side chains on ricin’s A (RTA) and B (RTB) subunits. In this study, we confirmed that the MR does indeed promote ricin binding, uptake and killing of monocytes in vitro. To assess the role of MR in the pathogenesis of ricin in vivo, MR knockout (MR−/−) mice were challenged with the equivalent of 2.5× or 5× LD50 of ricin by intraperitoneal injection. We found that MR−/− mice were significantly more susceptible to toxin-induced death than their age-matched, wild-type control counterparts. These data are consistent with a role for the MR in scavenging and degradation of ricin, not facilitating its uptake and toxicity in vivo.
Keywords: toxin; pathogenesis; C-type lectins; biodefense
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MDPI and ACS Style
Gage, E.; Hernandez, M.O.; O’Hara, J.M.; McCarthy, E.A.; Mantis, N.J. Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin. Toxins 2011, 3, 1131-1145.
Gage E, Hernandez MO, O’Hara JM, McCarthy EA, Mantis NJ. Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin. Toxins. 2011; 3(9):1131-1145.
Gage, Emily; Hernandez, Maria O.; O’Hara, Joanne M.; McCarthy, Elizabeth A.; Mantis, Nicholas J. 2011. "Role of the Mannose Receptor (CD206) in Innate Immunity to Ricin Toxin." Toxins 3, no. 9: 1131-1145.