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Inhibitors of the Cellular Trafficking of Ricin
Laboratory of Molecular Toxinology and Biotechnology (LTMB), Molecular engineering of proteins (SIMOPRO), Life Sciences Division (DSV), Institute of Biology and Technology Saclay (iBiTec-S), French Alternative Energies and Atomic Energy Commission (CEA), F-91191 Gif sur Yvette, France
Institut Curie/CNRS UMR144, Centre de Recherche, Traffic, Signaling, and Delivery Laboratory, 26 rue d’Ulm, F-75248 Paris Cedex 05, France
* Author to whom correspondence should be addressed.
Received: 23 November 2011; in revised form: 22 December 2011 / Accepted: 23 December 2011 / Published: 6 January 2012
(This article belongs to the Special Issue Ricin Toxin
Abstract: Throughout the last decade, efforts to identify and develop effective inhibitors of the ricin toxin have focused on targeting its N-glycosidase activity. Alternatively, molecules disrupting intracellular trafficking have been shown to block ricin toxicity. Several research teams have recently developed high-throughput phenotypic screens for small molecules acting on the intracellular targets required for entry of ricin into cells. These screens have identified inhibitory compounds that can protect cells, and sometimes even animals against ricin. We review these newly discovered cellular inhibitors of ricin intoxication, discuss the advantages and drawbacks of chemical-genetics approaches, and address the issues to be resolved so that the therapeutic development of these small-molecule compounds can progress.
Keywords: ricin; chemical genetics; retrograde transport; small-molecule inhibitor
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Cite This Article
MDPI and ACS Style
Barbier, J.; Bouclier, C.; Johannes, L.; Gillet, D. Inhibitors of the Cellular Trafficking of Ricin. Toxins 2012, 4, 15-27.
Barbier J, Bouclier C, Johannes L, Gillet D. Inhibitors of the Cellular Trafficking of Ricin. Toxins. 2012; 4(1):15-27.
Barbier, Julien; Bouclier, Céline; Johannes, Ludger; Gillet, Daniel. 2012. "Inhibitors of the Cellular Trafficking of Ricin." Toxins 4, no. 1: 15-27.