Special Issue "Clinical Use of Botulinum Toxins"

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A special issue of Toxins (ISSN 2072-6651).

Deadline for manuscript submissions: closed (31 August 2012)

Special Issue Editor

Guest Editor
Prof. Dr. Bahman Jabbari
Department of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA
E-Mail: bahman.jabbari@yale.edu

Special Issue Information

Dear Colleagues,

Introduction of Botulinum toxins(BoNTs) as therapeutic agents in clinical medicine have significantly improved management of involuntary movement disorders, debilitating spasticity and pain associated with a number of medical ailments. Animal data have shown that BoNTs do not only block the release of acetylcholine from presynaptic vesicles but also inhibit the release of a number of neurotransmitters and peptides most notable among them pain modulators (glutamate, substance P, calcitonin gene related peptide). The goal of this issue is to provide latest information about clinical utility of the BoNTs in clinical medicine. Those clinical conditions in which blinded and placebo controlled studies indicate efficacy is covered in details. The efficacy will be defined according to the guidelines of the American Academy of Neurology. The areas with potential efficacy based on smaller blinded studies or multiple prospective open observations will be mentioned briefly at the end of this issue.

The topics of this issue include: The molecular structure and mechanisms of action of botulinum toxins, blepharospasm, hemifacial spasm and facial dystonias, cervical dystonia and focal limb dystonia, headache and other pain disorders, conditions of increased muscle tone (spasicity and rigidity), genitourinary and gastrointestinal indications, orthopaedic indications , authonomic disorders (sialorhea and hyperhidrosis), tremors and tics, cosmetic indications, potential indications for future use.

Prof. Dr. Bahman Jabbari
Guest Editor

Keywords

  • botulinum toxin
  • pain
  • headaches
  • spasticiy
  • dysonia
  • sialorrhea
  • hyperhidrosis
  • blepharospasm
  • hemifacial spasm
  • tremor

Published Papers (13 papers)

Toxins 2013, 5(4), 776-783; doi:10.3390/toxins5040776
Received: 19 March 2013; in revised form: 12 April 2013 / Accepted: 15 April 2013 / Published: 23 April 2013
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Toxins 2013, 5(2), 249-266; doi:10.3390/toxins5020249
Received: 10 December 2012; in revised form: 17 January 2013 / Accepted: 23 January 2013 / Published: 4 February 2013
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Toxins 2013, 5(1), 93-105; doi:10.3390/toxins5010093
Received: 17 September 2012; in revised form: 12 December 2012 / Accepted: 5 January 2013 / Published: 11 January 2013
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Toxins 2013, 5(1), 73-83; doi:10.3390/toxins5010073
Received: 26 September 2012; in revised form: 25 December 2012 / Accepted: 27 December 2012 / Published: 8 January 2013
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Toxins 2013, 5(1), 60-72; doi:10.3390/toxins5010060
Received: 30 September 2012; in revised form: 14 December 2012 / Accepted: 24 December 2012 / Published: 7 January 2013
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Toxins 2013, 5(1), 16-24; doi:10.3390/toxins5010016
Received: 19 November 2012; in revised form: 19 December 2012 / Accepted: 21 December 2012 / Published: 28 December 2012
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Toxins 2012, 4(12), 1415-1426; doi:10.3390/toxins4121415
Received: 30 August 2012; in revised form: 12 November 2012 / Accepted: 21 November 2012 / Published: 27 November 2012
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Toxins 2012, 4(11), 1404-1414; doi:10.3390/toxins4111404
Received: 3 September 2012; in revised form: 24 October 2012 / Accepted: 9 November 2012 / Published: 20 November 2012
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Toxins 2012, 4(11), 1223-1235; doi:10.3390/toxins4111223
Received: 3 September 2012; in revised form: 25 October 2012 / Accepted: 31 October 2012 / Published: 7 November 2012
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Toxins 2012, 4(11), 1196-1222; doi:10.3390/toxins4111196
Received: 6 July 2012; in revised form: 2 October 2012 / Accepted: 29 October 2012 / Published: 7 November 2012
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Toxins 2012, 4(11), 956-961; doi:10.3390/toxins4110956
Received: 31 August 2012; in revised form: 25 September 2012 / Accepted: 18 October 2012 / Published: 24 October 2012
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Toxins 2012, 4(10), 913-939; doi:10.3390/toxins4100913
Received: 13 August 2012; in revised form: 9 October 2012 / Accepted: 12 October 2012 / Published: 19 October 2012
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Toxins 2012, 4(8), 605-619; doi:10.3390/toxins4080605
Received: 27 June 2012; in revised form: 9 August 2012 / Accepted: 10 August 2012 / Published: 13 August 2012
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Last update: 5 March 2014

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