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Toxins 2012, 4(11), 1404-1414; doi:10.3390/toxins4111404
Review

Botulinum Toxin Physiology in Focal Hand and Cranial Dystonia

Received: 3 September 2012 / Revised: 24 October 2012 / Accepted: 9 November 2012 / Published: 20 November 2012
(This article belongs to the Special Issue Clinical Use of Botulinum Toxins)
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Abstract

The safety and efficacy of botulinum toxin for the treatment of focal hand and cranial dystonias are well-established. Studies of these adult-onset focal dystonias reveal both shared features, such as the dystonic phenotype of muscle hyperactivity and overflow muscle contraction and divergent features, such as task specificity in focal hand dystonia which is not a common feature of cranial dystonia. The physiologic effects of botulinum toxin in these 2 disorders also show both similarities and differences. This paper compares and contrasts the physiology of focal hand and cranial dystonias and of botulinum toxin in the management of these disorders.
Keywords: dystonia; blepharospasm; Meige syndrome; writer’s cramp; botulinum toxin; physiology dystonia; blepharospasm; Meige syndrome; writer’; s cramp; botulinum toxin; physiology
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Karp, B.I. Botulinum Toxin Physiology in Focal Hand and Cranial Dystonia. Toxins 2012, 4, 1404-1414.

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