Special Issue "Antivenom and Venom Therapeutics"

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A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Animal Venoms".

Deadline for manuscript submissions: closed (30 June 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Bryan Grieg Fry
Venom Evolution Laboratory, School of Biological Sciences, University of Queensland, St. Lucia, QLD, 4072, Australia
Website: http://www.venomdoc.com
E-Mail: bgfry@uq.edu.au
Interests: venom molecular evolution; phylogenetics and structure-function relationships; toxins

Special Issue Information

Dear Colleagues,

Antivenom is the only scientifically-validated treatment against snakebite and is formulated as either purifyed IgGs or as pepsin (F(ab/)2)/papain (Fab) cleaved fragments raised against venoms of single (monospecific) or multiple snake species (polyspecific). Although the treatment aims to neutralize the toxic components of snake venom, its formulation frequently fails to take into account their distinct variation in representation and immunogenicity. Consequently, the often low, clinically-relevant fraction needed to achieve reversal of envenoming frequently leads to the administration of life-threatening volumes that compromise the effectiveness of the treatment and further increase its cost and availability. This Special Issue of Toxins aims to provide a comprehensive look at the challenges of antivenom therapy and the current strategies for improving such therapy.

Dr. Bryan Fry
Dr. Camila Renjifo
Guest Editors

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs).


Keywords

  • antivenom
  • snakebites
  • immunization
  • immunoglobulins
  • snake venom
  • toxin
  • envenoming

Published Papers (8 papers)

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Displaying article 1-8
p. 3388-3405
by , , ,  and
Toxins 2014, 6(12), 3388-3405; doi:10.3390/toxins6123388
Received: 8 November 2014; in revised form: 3 December 2014 / Accepted: 9 December 2014 / Published: 15 December 2014
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(This article belongs to the Special Issue Antivenom and Venom Therapeutics)
p. 2899-2911
by ,  and
Toxins 2014, 6(10), 2899-2911; doi:10.3390/toxins6102899
Received: 25 August 2014; in revised form: 16 September 2014 / Accepted: 23 September 2014 / Published: 29 September 2014
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(This article belongs to the Special Issue Antivenom and Venom Therapeutics)
p. 2594-2604
by , , ,  and
Toxins 2014, 6(9), 2594-2604; doi:10.3390/toxins6092594
Received: 18 July 2014; Accepted: 18 August 2014 / Published: 25 August 2014
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(This article belongs to the Special Issue Antivenom and Venom Therapeutics)
p. 2541-2567
by , , , , ,  and
Toxins 2014, 6(8), 2541-2567; doi:10.3390/toxins6082541
Received: 4 June 2014; in revised form: 16 July 2014 / Accepted: 4 August 2014 / Published: 21 August 2014
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(This article belongs to the Special Issue Antivenom and Venom Therapeutics)
p. 2568-2579
by , , , , ,  and
Toxins 2014, 6(8), 2568-2579; doi:10.3390/toxins6082568
Received: 26 May 2014; in revised form: 28 July 2014 / Accepted: 14 August 2014 / Published: 21 August 2014
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(This article belongs to the Special Issue Antivenom and Venom Therapeutics)
p. 2471-2482
by , , ,  and
Toxins 2014, 6(8), 2471-2482; doi:10.3390/toxins6082471
Received: 12 June 2014; in revised form: 13 August 2014 / Accepted: 13 August 2014 / Published: 19 August 2014
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(This article belongs to the Special Issue Antivenom and Venom Therapeutics)
p. 1667-1695
by  and
Toxins 2014, 6(5), 1667-1695; doi:10.3390/toxins6051667
Received: 13 March 2014; in revised form: 9 May 2014 / Accepted: 14 May 2014 / Published: 23 May 2014
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(This article belongs to the Special Issue Antivenom and Venom Therapeutics)
p. 1526-1558
by , , , , , , , ,  and
Toxins 2014, 6(5), 1526-1558; doi:10.3390/toxins6051526
Received: 15 February 2014; in revised form: 20 April 2014 / Accepted: 5 May 2014 / Published: 13 May 2014
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(This article belongs to the Special Issue Antivenom and Venom Therapeutics)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Cancer cell growth inhibitory effect of bee venom via increase of death receptor 3 expression and inactivation of NF-kappaB in NSCLC cells
Author: Jin Tae Hong
Affiliation: College of Pharmacy, Chungbuk National University
Abstract: Our studies and others have demonstrated bee venom (BV) have anti-cancer activity in several cancer cells. However, the effects of BV on the lung cancer cell growth have not been reported. Cell viability was determined with trypan blue uptake, soft agar formation as well as DAPI and TUNEL assay. Cell death related protein expression was determined with Western blotting. EMSA was used nuclear factor kappaB (NF-kappaB) activity assay. BV (1-5 μg/ml) inhibited growth of lung cancer cells by induction of apoptosis in a dose dependent manner in A549 and NCI-H460. Consistent with apoptotic cell death, expression of DR3 and DR6 was significantly increased. However, deletion of DRs by small interfering RNA significantly reversed BV induced cell growth inhibitory effects. Expression of pro-apoptotic proteins (caspase-3 and Bax) were concomitantly increased, but the nuclear factor kappaB (NF-kB) activity and expression of Bcl-2 were inhibited. Combination treatment of tumor necrosis factor (TNF)-like weak inducer of apoptosis, TNF-related apoptosis-inducing ligand, docetaxel and cisplatin, with BV synergistically inhibited the both lung cancer cell growth with further down regulation of NF-kB activity. These results show that BV induces apoptotic cell death in lung cancer cells through enhancement of DR3 expression and inhibition of NF-kappaB pathway.

Last update: 31 March 2014

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