Special Issue "Toxicities of Therapeutic Agents Used in Medicine"

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A special issue of Toxics (ISSN 2305-6304).

Deadline for manuscript submissions: closed (30 April 2015)

Special Issue Editors

Guest Editor
Prof. Guido Cavaletti
Unità di Neurologia Sperimentale e Centro di Neuroscienze di Milano, Dipartimento di Chirurgia e Medicina traslazionale, Università di Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy
Website: http://www.enu.dcmt.unimib.it/doctor/guido-cavaletti/
Interests: peripheral neuropathies; antineoplastic drugs; animal models; clinical trials
Guest Editor
Dr. Valentina Carozzi
Unità di Neurologia Sperimentale e Centro di Neuroscienze di Milano, Dipartimento di Chirurgia e Medicina traslazionale, Università di Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy
Website: http://www.enu.dcmt.unimib.it/doctor/valentina-carozzi/
Interests: peripheral neuropathies, antineoplastic drugs, animal models

Special Issue Information

Dear Colleagues,

Pharmacological treatment of human disorders has afforded a remarkable improvement in the management of severe illnesses, but the use of effective drugs can also be associated with “off-target” side effects which might have an impact on the survival and/or the patients’ quality of life.

Among the wide spectrum of toxicities, neurotoxicity represents one of the main concerns since the nervous system has limited capacity to recover from damage and supportive treatments are frequently ineffective.

The central nervous system is protected by the blood-brain barrier and most of the putative toxic agents are unable to cross the intact barrier, but this protection might be overcome by the administration of very high doses of drugs or might be less effective in the course of diseases such as brain tumours and infections. However, the peripheral nervous system is much less effectively protected and specific regions, such as the dorsal root ganglia, allow a very easy access to toxic substances reaching the nervous system through the bloodstream.

A full comprehension of the possible neurotoxicity of systemic as well as of local treatments represents a cornerstone in the knowledge of any physician, and it should not be limited to specialists in clinical neurosciences. The aim of this Special Issue is to provide the necessary background to enhance this comprehension, with a focus on the most frequent clinical syndromes in different fields of medicine.

Prof. Guido Cavaletti
Dr. Valentina Carozzi
Guest Editors

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.

Keywords

  • nervous system
  • toxicity
  • clinical
  • animal models
  • diagnosis
  • treatment

Published Papers (9 papers)

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Displaying article 1-9
p. 304-321
by ,  and
Toxics 2015, 3(3), 304-321; doi:10.3390/toxics3030304
Received: 12 June 2015 / Revised: 22 July 2015 / Accepted: 31 July 2015 / Published: 7 August 2015
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(This article belongs to the Special Issue Toxicities of Therapeutic Agents Used in Medicine)
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p. 322-341
by ,  and
Toxics 2015, 3(3), 322-341; doi:10.3390/toxics3030322
Received: 22 May 2015 / Revised: 28 July 2015 / Accepted: 3 August 2015 / Published: 7 August 2015
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(This article belongs to the Special Issue Toxicities of Therapeutic Agents Used in Medicine)
p. 294-303
by
Toxics 2015, 3(3), 294-303; doi:10.3390/toxics3030294
Received: 13 May 2015 / Revised: 15 July 2015 / Accepted: 21 July 2015 / Published: 27 July 2015
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(This article belongs to the Special Issue Toxicities of Therapeutic Agents Used in Medicine)
p. 268-293
by , ,  and
Toxics 2015, 3(3), 268-293; doi:10.3390/toxics3030268
Received: 26 April 2015 / Revised: 8 July 2015 / Accepted: 9 July 2015 / Published: 15 July 2015
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(This article belongs to the Special Issue Toxicities of Therapeutic Agents Used in Medicine)
p. 224-248
by , , , , ,  and
Toxics 2015, 3(2), 224-248; doi:10.3390/toxics3020224
Received: 30 April 2015 / Revised: 9 June 2015 / Accepted: 9 June 2015 / Published: 19 June 2015
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(This article belongs to the Special Issue Toxicities of Therapeutic Agents Used in Medicine)
p. 198-223
by ,  and
Toxics 2015, 3(2), 198-223; doi:10.3390/toxics3020198
Received: 24 April 2015 / Revised: 26 May 2015 / Accepted: 1 June 2015 / Published: 5 June 2015
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(This article belongs to the Special Issue Toxicities of Therapeutic Agents Used in Medicine)
p. 187-197
by
Toxics 2015, 3(2), 187-197; doi:10.3390/toxics3020187
Received: 3 May 2015 / Revised: 20 May 2015 / Accepted: 26 May 2015 / Published: 29 May 2015
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(This article belongs to the Special Issue Toxicities of Therapeutic Agents Used in Medicine)
p. 152-169
by  and
Toxics 2015, 3(2), 152-169; doi:10.3390/toxics3020152
Received: 1 April 2015 / Revised: 19 April 2015 / Accepted: 21 April 2015 / Published: 28 April 2015
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(This article belongs to the Special Issue Toxicities of Therapeutic Agents Used in Medicine)
p. 75-88
by  and
Toxics 2015, 3(1), 75-88; doi:10.3390/toxics3010075
Received: 22 January 2015 / Revised: 16 February 2015 / Accepted: 26 February 2015 / Published: 5 March 2015
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Last update: 10 August 2015

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