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Toxics 2015, 3(3), 304-321; doi:10.3390/toxics3030304

Current View in Platinum Drug Mechanisms of Peripheral Neurotoxicity

1
Experimental Neurology Unit and Milan Center for Neuroscience, Department of Surgery and Translational Medicine, University of Milano-Bicocca, Monza (MB) 20900, Italy
2
PhD Program in Neuroscience, University of Milano-Bicocca, Monza (MB) 20900, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Cheng Wang
Received: 12 June 2015 / Revised: 22 July 2015 / Accepted: 31 July 2015 / Published: 7 August 2015
(This article belongs to the Special Issue Toxicities of Therapeutic Agents Used in Medicine)
View Full-Text   |   Download PDF [419 KB, uploaded 7 August 2015]   |  

Abstract

Peripheral neurotoxicity is the dose-limiting factor for clinical use of platinum derivatives, a class of anticancer drugs which includes cisplatin, carboplatin, and oxaliplatin. In particular cisplatin and oxaliplatin induce a severe peripheral neurotoxicity while carboplatin is less neurotoxic. The mechanisms proposed to explain these drugs’ neurotoxicity are dorsal root ganglia alteration, oxidative stress involvement, and mitochondrial dysfunction. Oxaliplatin also causes an acute and reversible neuropathy, supposed to be due by transient dysfunction of the voltage-gated sodium channels of sensory neurons. Recent studies suggest that individual genetic variation may play a role in the pathogenesis of platinum drug neurotoxicity. Even though all these mechanisms have been investigated, the pathogenesis is far from clearly defined. In this review we will summarize the current knowledge and the most up-to-date hypotheses on the mechanisms of platinum drug-induced peripheral neurotoxicity. View Full-Text
Keywords: platinum drugs; peripheral neurotoxicity; mechanisms of action platinum drugs; peripheral neurotoxicity; mechanisms of action
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Chiorazzi, A.; Semperboni, S.; Marmiroli, P. Current View in Platinum Drug Mechanisms of Peripheral Neurotoxicity. Toxics 2015, 3, 304-321.

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