Next Article in Journal
Additivity and Interactions in Ecotoxicity of Pollutant Mixtures: Some Patterns, Conclusions, and Open Questions
Next Article in Special Issue
Transcriptional Suppression of Renal Antioxidant Enzyme Systems in Guinea Pigs Exposed to Polymerized Cell-Free Hemoglobin
Previous Article in Journal / Special Issue
Current View in Platinum Drug Mechanisms of Peripheral Neurotoxicity
Article Menu

Export Article

Open AccessReview
Toxics 2015, 3(3), 322-341; doi:10.3390/toxics3030322

Axonal Transport Impairment in Chemotherapy-Induced Peripheral Neuropathy

1
Experimental Neurology Unit and Milan Center for Neuroscience, Department of Surgery and Translational Medicine, University of Milano-Bicocca, via Cadore 48, 20900 Monza, Italy
2
PhD Neuroscience Program, University of Milano-Bicocca, via Cadore 48, 20900 Monza, Italy
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Cheng Wang
Received: 22 May 2015 / Revised: 28 July 2015 / Accepted: 3 August 2015 / Published: 7 August 2015
(This article belongs to the Special Issue Toxicities of Therapeutic Agents Used in Medicine)
View Full-Text   |   Download PDF [449 KB, uploaded 7 August 2015]

Abstract

Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a dose-limiting side effect of several antineoplastic drugs which significantly reduces patients’ quality of life. Although different molecular mechanisms have been investigated, CIPN pathobiology has not been clarified yet. It has largely been recognized that Dorsal Root Ganglia are the main targets of chemotherapy and that the longest nerves are the most damaged, together with fast axonal transport. Indeed, this bidirectional cargo-specific transport has a pivotal role in neuronal function and its impairment is involved in several neurodegenerative and neurodevelopmental diseases. Literature data demonstrate that, despite different mechanisms of action, all antineoplastic agents impair the axonal trafficking to some extent and the severity of the neuropathy correlates with the degree of damage on this bidirectional transport. In this paper, we will examine the effect of the main old and new chemotherapeutic drug categories on axonal transport, with the aim of clarifying their potential mechanisms of action, and, if possible, of identifying neuroprotective strategies, based on the knowledge of the alterations induced by each drugs. View Full-Text
Keywords: axonal transport; neurotoxicity; peripheral neuropathy axonal transport; neurotoxicity; peripheral neuropathy
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Nicolini, G.; Monfrini, M.; Scuteri, A. Axonal Transport Impairment in Chemotherapy-Induced Peripheral Neuropathy. Toxics 2015, 3, 322-341.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Toxics EISSN 2305-6304 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top