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Special Issue "Sensors for Glycoproteins and Glycated Proteins"

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 15 May 2017

Special Issue Editor

Guest Editor
Prof. Dr. Junichi Anzai

Graduate School of Pharmaceutical Sciences Tohoku University Aoba 6-3, Aramaki, Aoba-ku, Sendai 980-8578, Japan
Website | E-Mail
Interests: biosensors; layer-by-layer films; microcapsules

Special Issue Information

Dear Colleagues,

This Special Issue focuses on biosensors for glycoproteins and glycated proteins. Biosensors for any type of glycoproteins, extrinsically glycated proteins, such as HbA1c and related compounds, are considered for publication in this Special Issue. These biosensors include optical sensors, such as colorimetric and fluorometric sensors, as well as electrochemical sensors in amperometric, voltametric, impedimetric, and potentiometric detection modes. Other biosensors, such as quartz crystal microbalance (QCM) sensors, are also welcome. Biosensors applicable to biomedical analysis, environmental monitoring, process control in food and pharmaceutical industries, and biological research are within the scope of this Special Issue. Submission of papers dealing with the construction of high-performance of biosensors based on metal and carbon nanomaterials is particularly encouraged. Both original research papers and review articles on the basic principle and applications of biosensors are solicited.

This Special Issue aims to promote the exchanges of ideas and the knowledge of scientists and engineers working in the communities of biosensors.

Prof. Dr. Junichi Anzai
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs).

 

Keywords

  • Optical and electrochemical sensors
  • Colorimetric and fluorometric sensors
  • Quartz crystal microbalance sensors
  • Enzyme sensors
  • Immunosensors
  • Aptamer sensors
  • Glycoproteins and glycated proteins
  • Lectin-based sensors
  • Glycated haemoglobin (HbA1c) sensors

Published Papers (3 papers)

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Research

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Open AccessCommunication Label-Free Detection of Human Glycoprotein (CgA) Using an Extended-Gated Organic Transistor-Based Immunosensor
Sensors 2016, 16(12), 2033; doi:10.3390/s16122033
Received: 30 September 2016 / Revised: 26 November 2016 / Accepted: 28 November 2016 / Published: 30 November 2016
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Abstract
Herein, we report on the fabrication of an extended-gated organic field-effect transistor (OFET)-based immunosensor and its application in the detection of human chromogranin A (hCgA). The fabricated OFET device possesses an extended-gate electrode immobilized with an anti-CgA antibody. The titration results of hCgA
[...] Read more.
Herein, we report on the fabrication of an extended-gated organic field-effect transistor (OFET)-based immunosensor and its application in the detection of human chromogranin A (hCgA). The fabricated OFET device possesses an extended-gate electrode immobilized with an anti-CgA antibody. The titration results of hCgA showed that the electrical changes in the OFET characteristics corresponded to the glycoprotein recognition ability of the monoclonal antibody (anti-CgA). The observed sensitivity (detection limit: 0.11 µg/mL) and selectivity indicate that the OFET-based immunosensor can be potentially applied to the rapid detection of the glycoprotein concentration without any labeling. Full article
(This article belongs to the Special Issue Sensors for Glycoproteins and Glycated Proteins)
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Open AccessArticle Single-Use Disposable Electrochemical Label-Free Immunosensor for Detection of Glycated Hemoglobin (HbA1c) Using Differential Pulse Voltammetry (DPV)
Sensors 2016, 16(7), 1024; doi:10.3390/s16071024
Received: 3 June 2016 / Revised: 26 June 2016 / Accepted: 28 June 2016 / Published: 1 July 2016
Cited by 2 | PDF Full-text (2914 KB) | HTML Full-text | XML Full-text
Abstract
A single-use disposable in vitro electrochemical immunosensor for the detection of HbA1c in undiluted human serum using differential pulse voltammetry (DPV) was developed. A three-electrode configuration electrochemical biosensor consisted of 10-nm-thin gold film working and counter electrodes and a thick-film printed Ag/AgCl reference
[...] Read more.
A single-use disposable in vitro electrochemical immunosensor for the detection of HbA1c in undiluted human serum using differential pulse voltammetry (DPV) was developed. A three-electrode configuration electrochemical biosensor consisted of 10-nm-thin gold film working and counter electrodes and a thick-film printed Ag/AgCl reference electrode was fabricated on a polyethylene terephthalate (PET) substrate. Micro-fabrication techniques including sputtering vapor deposition and thick-film printing were used to fabricate the biosensor. This was a roll-to-roll cost-effective manufacturing process making the single-use disposable in vitro HbA1c biosensor a reality. Self-assembled monolayers of 3-Mercaptopropionic acid (MPA) were employed to covalently immobilize anti-HbA1c on the surface of gold electrodes. Electrochemical impedance spectroscopy (EIS) and X-ray photoelectron spectroscopy (XPS) confirmed the excellent coverage of MPA-SAM and the upward orientation of carboxylic groups. The hindering effect of HbA1c on the ferricyanide/ferrocyanide electron transfer reaction was exploited as the HbA1c detection mechanism. The biosensor showed a linear range of 7.5–20 µg/mL of HbA1c in 0.1 M PBS. Using undiluted human serum as the test medium, the biosensor presented an excellent linear behavior (R2 = 0.999) in the range of 0.1–0.25 mg/mL of HbA1c. The potential application of this biosensor for in vitro measurement of HbA1c for diabetic management was demonstrated. Full article
(This article belongs to the Special Issue Sensors for Glycoproteins and Glycated Proteins)
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Review

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Open AccessReview Recent Progress in Electrochemical Biosensors for Glycoproteins
Sensors 2016, 16(12), 2045; doi:10.3390/s16122045
Received: 5 October 2016 / Revised: 22 November 2016 / Accepted: 29 November 2016 / Published: 1 December 2016
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Abstract
This review provides an overview of recent progress in the development of electrochemical biosensors for glycoproteins. Electrochemical glycoprotein sensors are constructed by combining metal and carbon electrodes with glycoprotein-selective binding elements including antibodies, lectin, phenylboronic acid and molecularly imprinted polymers. A recent trend
[...] Read more.
This review provides an overview of recent progress in the development of electrochemical biosensors for glycoproteins. Electrochemical glycoprotein sensors are constructed by combining metal and carbon electrodes with glycoprotein-selective binding elements including antibodies, lectin, phenylboronic acid and molecularly imprinted polymers. A recent trend in the preparation of glycoprotein sensors is the successful use of nanomaterials such as graphene, carbon nanotube, and metal nanoparticles. These nanomaterials are extremely useful for improving the sensitivity of glycoprotein sensors. This review focuses mainly on the protocols for the preparation of glycoprotein sensors and the materials used. Recent improvements in glycoprotein sensors are discussed by grouping the sensors into several categories based on the materials used as recognition elements. Full article
(This article belongs to the Special Issue Sensors for Glycoproteins and Glycated Proteins)
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