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Sensors 2017, 17(8), 1798; https://doi.org/10.3390/s17081798

Current Status of HbA1c Biosensors

School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China
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Received: 24 June 2017 / Revised: 24 July 2017 / Accepted: 1 August 2017 / Published: 4 August 2017
(This article belongs to the Special Issue Sensors for Glycoproteins and Glycated Proteins)
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Abstract

Glycated hemoglobin (HbA1c) is formed via non-enzymatic glycosylation reactions at the α–amino group of βVal1 residues in the tetrameric Hb, and it can reflect the ambient glycemic level over the past two to three months. A variety of HbA1c detection methods, including chromatography, immunoassay, enzymatic measurement, electrochemical sensor and capillary electrophoresis have been developed and used in research laboratories and in clinics as well. In this review, we summarize the current status of HbA1c biosensors based on the recognition of the sugar moiety on the protein and also their applications in the whole blood sample measurements. View Full-Text
Keywords: glycated hemoglobin (HbA1c); biosensor; boronic acid; antibody; fructosyl valine glycated hemoglobin (HbA1c); biosensor; boronic acid; antibody; fructosyl valine
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Lin, H.; Yi, J. Current Status of HbA1c Biosensors. Sensors 2017, 17, 1798.

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