Recent Progress in Microencapsulation and Nanoencapsulation for Pharmaceutical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 20 October 2024 | Viewed by 497

Special Issue Editor


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Guest Editor
Faculty of Pharmacy, Department of Pharmaceutical technology and Cosmetology, University of Belgrade, Belgrade, Serbia
Interests: microencapsulation; nanoencapsulation; formulation development; controled drug delivery; nanotechnology; polymer based drug delivery systems; lipid based drug delivery systems
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Special Issue Information

Dear Colleagues,

The encapsulation of pharmaceutical ingredients in particulate and vesicular carriers on a microscale (microencapsulation) and a nanoscale (nanoencapsulation) represents one of the pillars of current drug development with clearly recognized potential for improving the quality, efficiency and safety of pharmaceutical products. The expansion of research in this area over the past half century has led to the extensive application of microencapsulation technologies in the pharmaceutical industry for both small molecules and macromolecules, thus overcoming different formulation and process challenges and achieving controlled drug release. The adaptation of microencapsulation technologies for nanoscale applications with the additional development of diverse exclusive nanotechnological platforms, as well as the progressive development of newly synthesized materials and the exploitation of excipients from renewable sources, may ensure the creation of a multitude of nanocarriers (e.g., nanoemulsions, microemulsions, polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid carriers, liposomes, and superparamagnetic iron oxide nanoparticles) with specific characteristics, including stimulus-controlled release for use in target drug delivery, diagnostics, and theranostics. This Special Issue aims to highlight the current progress in the design and physicochemical characterization of micro- and nano-carriers, the assessment of their encapsulation capacity and in vitro/in vivo performances, as well as the permanently demanding aspects of formulation and process development for micro- and nano-encapsulated active ingredients.

Prof. Dr. Ljiljana Đekić
Guest Editor

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Keywords

  • microencapsulation
  • nanoencapsulation
  • small molecules
  • macromolecules
  • microparticles
  • nanoparticles
  • vesicles
  • nanodispersions
  • nanotechnology
  • target drug delivery
  • stimulus-controlled drug release
  • theranostics
  • formulation development
  • process optimization

Published Papers (1 paper)

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Research

29 pages, 3038 KiB  
Article
Carbomer Hydrogels with Microencapsulated α-Tocopherol: Focus on the Biocompatibility of the Microcapsules, Topical Application Attributes, and In Vitro Release Study
by Ljiljana Đekić, Jelena Milinković Budinčić, Dušanka Stanić, Jadranka Fraj and Lidija Petrović
Pharmaceutics 2024, 16(5), 628; https://doi.org/10.3390/pharmaceutics16050628 - 7 May 2024
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Abstract
The microencapsulation of α-tocopherol based on the complex coacervation of low-molecular-weight chitosan (LMWC) and sodium lauryl ether sulphate (SLES) without harmful crosslinkers can provide biocompatible carriers that protect it from photodegradation and air oxidation. In this study, the influence of the microcapsule wall [...] Read more.
The microencapsulation of α-tocopherol based on the complex coacervation of low-molecular-weight chitosan (LMWC) and sodium lauryl ether sulphate (SLES) without harmful crosslinkers can provide biocompatible carriers that protect it from photodegradation and air oxidation. In this study, the influence of the microcapsule wall composition on carrier performance, compatibility with a high-water-content vehicle for topical application, and release of α-tocopherol were investigated. Although the absence of aldehyde crosslinkers decreased the encapsulation efficiency of α-tocopherol (~70%), the variation in the LMWC/SLES mass ratio (2:1 or 1:1) had no significant effect on the moisture content and microcapsule size. The prepared microcapsule-loaded carbomer hydrogels were soft semisolids with pseudoplastic flow behavior. The integrity of microcapsules embedded in the hydrogel was confirmed by light microscopy. The microcapsules reduced the pH, apparent viscosity, and hysteresis area of the hydrogels, while increasing their spreading ability on a flat inert surface and dispersion rate in artificial sweat. The in vitro release of α-tocopherol from crosslinker-free microcapsule-loaded hydrogels was diffusion-controlled. The release profile was influenced by the LMWC/SLES mass ratio, apparent viscosity, type of synthetic membrane, and acceptor medium composition. Better data quality for the model-independent analysis was achieved when a cellulose nitrate membrane and ethyl alcohol 60% w/w as acceptor medium were used. Full article
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