Special Issue "Biofilm-Based Nosocomial Infections"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (30 September 2014)
Prof. Dr. Gianfranco Donelli
Microbial Biofilm Laboratory (LABIM), IRCCS "Fondazione Santa Lucia", Via Ardeatina 306, 00179 Rome, Italy
Fax: +39 06 51501306
Interests: microbiology; microbial biofilms; healthcare-associated infections; biomaterial-associated infections; role of toxins and other virulence factors in microbial pathogenesis
Microbial biofilms have been implicated in a large number of acute and chronic infections, as well as in the failure of antibiotic treatment, particularly in hospitalized patients. In fact, the well-known persistence in the nosocomial environment of multidrug resistant microorganisms is believed to be highly promoted by the ability of the great majority of the involved bacterial and fungal species to adhere on living or abiotic surfaces, and to grow in sessile mode, to form single- or multi-species biofilms. In these communities, microbes grow encased in a hydrated matrix of extracellular polymeric substances produced by themselves and are well protected from the host immune response and the attack of antimicrobial molecules. Thus, the establishment of microbial biofilm communities on the mucosal and soft tissues of hospitalized patients, as well as on the surfaces of indwelling devices and medical instruments, is expected to have a great influence on the success of the antibiotic therapies against most of the bugs involved in nosocomial infections, being biofilm-growing bacteria and fungi much less susceptible to antibiotics.
The aim of this Special Issue will be to report the state-of-art developments in the field of biofilm-based nosocomial infections that can be acquired by patients in both general hospitals and long-term care settings. Particularly, the involvement of biofilms in medical device-related infections and other healthcare-associated infections, which have so far been underestimated and scarcely investigated, will be reviewed.
Prof. Dr. Gianfranco Donelli
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed Open Access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 600 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.
- bacterial biofilms
- fungal biofilms
- nosocomial Infections
- antibiotic resistance
- healthcare-associated infections
- multidrug resistant microorganisms
- medical devices
- medical instruments
- general hospitals
- long-term care settings