Special Issue "Synthesis and Extraction in Supercritical Fluids"
QuicklinksA special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 March 2012)
Special Issue Editor
Guest Editor
Prof. Dr. Pedro Lozano
Department of Biochemistry and Molecular Biology "B", Faculty of Chemistry, University of Murcia, E-30.100- MURCIA, Spain
E-Mail: plozanor@um.es
Special Issue Information
Dear Colleagues,
One of the major challenges to be faced by the chemical industry at the beginning of this century is the development of more efficient and environmentally friendly synthetic processes. Supercritical fluids (SCFs) are becoming increasingly popular as media for clean chemical syntheses, including the development of specialized materials. Additionally to the classic application to the extraction of pure biologically active compounds from raw materials, the unique properties of SCFs have opened a broad number of applications in the synthesis of fine chemicals by (bio)catalytic transformations, the preparation of advanced materials (e.g. nanoparticles, catalysts, polymers, porous materials, etc), as well as the design of continuous clean synthetic processes. In the last decade, furthermore, the combination of SCFs with others clean non-aqueous solvents, such as ionic liquids (ILs), was appeared as a clear strategy to develop integral green multicatalytic processes. SCFs/ILs biphasic mixtures seem to be perfect tools for green chemical synthesis, and the interest for application at industrial scale is beyond doubt. The door leading to a green chemical industry is open.
This Special Issue on Synthesis in Supercritical Fluids will offer an attractive forum to present the (bio)catalytic synthesis and/or the down-stream processes for fine chemicals, nutraceuticals, fuels, etc., including the preparation and/or application of advanced materials in SCFs. I strongly encourage authors to submit papers for this Special Issue on Synthesis in Supercritical Fluids, within the scope of Molecules. I hope that the topics covered will reflect the potential and the excitement of SCFs in the green chemical community.
Prof. Dr. Pedro Lozano
Guest Editor
Submission
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed Open Access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs).
Keywords
- catalysts in SCFs: Preparation and applications
- continuous synthetic processes in SCFs
- biocatalysts in SCFs
- nanoparticles in SCFs
- SCFs in biofuels technology
- SCFs in green chemistry
- supercritical extraction
- supercritical fluids / ionic liquids systems
Published Papers (1 paper)
 Molecules 2012, 17(3), 2628-2642; doi:10.3390/molecules17032628
Received: 16 December 2011; in revised form: 23 February 2012 / Accepted: 28 February 2012 / Published: 5 March 2012
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Planned Papers
Title: Coenzyme Q10 Microparticles Formation with Supercritical Carbon Dioxide
Authors: C. H. Ortiz-Estrada, C. Y. Díaz-Díaz, J. A. Quezada-Gall, R. Pedroza-Isla and M. S. Vergara-Mendoza
Affiliation: Departamento de Ingeniería y Ciencias Químicas, Universidad Iberoamericana, Ciudad de México. Prol. Paseo de la Reforma 880, Lomas de Santa Fe, México, C.P. 01219, Distrito Federal, Mexico; E-Mail: ciro.ortiz@uia.mx
Abstract: The coenzyme Q10 is an antioxidant powerful used in the treatment of cardiovascular, neurodegenerative and cancer diseases. However their hydrophobic nature limits its applications strongly, since the human body absorbs it with difficulty, it is hence that intended to increase its bioavailability, diminishing the particle size using supercritical carbon dioxide. Experimentally was determined the phase behavior of the coenzyme in the supercritical system. With the equilibria data was carried out an experimental factorial design 2k for the microparticles elaboration, being determined the effect in the morphology and size with the temperature, coQ10 concentrations and nozzle diameter. The microparticles were characterized by IR spectrophotometry and Chromatography, to verify their chemical fundamental structure; size and morphology with Scanning Electron Microscope was determined, finding a significant decrease of the particle size and the modification of their physical structure. The antioxidant power was also evaluated by the micronization; finding an increment of this property. Finally to evaluate the bioavailability the kinetics of solubility it was determined in ethanol, finding a substantial increment in the solubilization speed of the coQ10 micronized with regard to the commercial one.
Last update: 30 September 2011