Next Article in Journal
The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR
Next Article in Special Issue
Solvent-Free Synthesis of Modified Pectin Compounds Promoted by Microwave Irradiation
Previous Article in Journal
Synthesis and Anticancer Activity of Di(3-thienyl)methanol and Di(3-thienyl)methane
Previous Article in Special Issue
Microwave Synthesis Under Solvent-Free Conditions and Spectral Studies of Some Mesoporphyrinic Complexes
Molecules 2012, 17(10), 11469-11483; doi:10.3390/molecules171011469
Article

Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions

, , ,  and *
Institute for Materials Chemistry and Engineering (IMCE), Kyushu University, Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
* Author to whom correspondence should be addressed.
Received: 24 August 2012 / Revised: 18 September 2012 / Accepted: 20 September 2012 / Published: 27 September 2012
(This article belongs to the Special Issue Solvent-Free Synthesis)
Download PDF [271 KB, uploaded 18 June 2014]

Abstract

Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl- or triphenylphosphine and Hunig’s base, and (3) the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation.
Keywords: aromatic nitration; green synthetic process; heterogeneous reaction; Morita-Baylis-Hillman reaction; one-pot Wittig-type olefination; solid reaction medium aromatic nitration; green synthetic process; heterogeneous reaction; Morita-Baylis-Hillman reaction; one-pot Wittig-type olefination; solid reaction medium
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote |
RIS
MDPI and ACS Style

Onitsuka, S.; Jin, Y.Z.; Shaikh, A.C.; Furuno, H.; Inanaga, J. Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions. Molecules 2012, 17, 11469-11483.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert