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Molecules 2012, 17(10), 11469-11483; doi:10.3390/molecules171011469
Article

Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions

, , ,  and *
Received: 24 August 2012; in revised form: 18 September 2012 / Accepted: 20 September 2012 / Published: 27 September 2012
(This article belongs to the Special Issue Solvent-Free Synthesis)
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Abstract: Silica gel was found to be an excellent medium for some useful organic transformations under organic solvent-free conditions, such as (1) the Friedel-Crafts-type nitration of arenes using commercial aqueous 69% nitric acid alone at room temperature, (2) one-pot Wittig-type olefination of aldehydes with activated organic halides in the presence of tributyl- or triphenylphosphine and Hunig’s base, and (3) the Morita-Baylis-Hillman reaction of aldehydes with methyl acrylate. After the reactions, the desired products were easily obtained in good to excellent yields through simple manipulation.
Keywords: aromatic nitration; green synthetic process; heterogeneous reaction; Morita-Baylis-Hillman reaction; one-pot Wittig-type olefination; solid reaction medium aromatic nitration; green synthetic process; heterogeneous reaction; Morita-Baylis-Hillman reaction; one-pot Wittig-type olefination; solid reaction medium
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Onitsuka, S.; Jin, Y.Z.; Shaikh, A.C.; Furuno, H.; Inanaga, J. Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions. Molecules 2012, 17, 11469-11483.

AMA Style

Onitsuka S, Jin YZ, Shaikh AC, Furuno H, Inanaga J. Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions. Molecules. 2012; 17(10):11469-11483.

Chicago/Turabian Style

Onitsuka, Satoaki; Jin, Yong Zhi; Shaikh, Ajam C.; Furuno, Hiroshi; Inanaga, Junji. 2012. "Silica Gel-Mediated Organic Reactions under Organic Solvent-Free Conditions." Molecules 17, no. 10: 11469-11483.


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