Special Issue "Natural Product Pre-fractionation"

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A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (30 May 2008)

Special Issue Editor

Guest Editor
Dr. John A. Beutler
Molecular Targets Development Program, Bldg.560-15 NCI at Frederick, Frederick, MD 21702-1201, USA
Website: http://mtdp.nci.nih.gov/
E-Mail:
Interests: natural products; cancer; HIV; plants; molecular targets

Published Papers

Click here to see a list of 2 papers that have been published in this special issue.

Special Issue Information

Summary

Natural products provide an unparalleled source of chemical diversity for discovery of important and interesting biologically active molecules. This bounty comes at a price, since crude extracts of natural products can be difficult to screen in bioassays, and must be fractionated with guidance from the bioassay to obtain pure compounds. If the active compounds are present in trace amounts this can become a very difficult and time-consuming process, or the activity may be missed altogether. Numerous companies and academic groups have therefore sought to remedy these problems by chromatographically separating the extract to various degrees of resolution. This issue will examine a spectrum of different approaches and provide details on the technical challenges involved, the costs, and the rewards in improved identification of novel natural products.

Leading papers

  1. Eldridge, G. R.; Vervoort, H. C.; Lee, C. M.; Cremin, P. A.; Williams, C. T.; Hart, S. M.; Goering, M. G.; O'Neil-Johnson, M.; Zeng, L. High-throughput method for the production and analysis of large natural product libraries for drug discovery. Anal.Chem. 2002, 74 (16), 3963-3971.
  2. Bindseil, K. U.; Jakupovic, J.; Wolf, D.; Lavayre, J.; Leboul, J.; van der Pyl, D. Pure compound libraries; a new perspective for natural product based drug discovery. Drug Discov. Today 2001, 6 (16), 840-847.


Submission

All papers should be submitted to molecules@mdpi.org with copy to the guest editor. To be published continuously until the deadline and papers will be listed together at the special websites.
Submitted papers should not have been previously published nor be currently under consideration for publication elsewhere. All papers are refereed through a peer review process. A guide for authors, sample copies and other relevant information for submitting papers are available on the Instructions for Authors page. Molecules is an international peer-reviewed quarterly journal published by Molecular Diversity Preservation International.
Please visit the Instructions for Authors page before submitting a paper. Open Access publication fees are 800 CHF per paper. English correction fees (250 CHF) will be added in certain cases (1050 CHF per paper for those papers that require extensive additional formatting and/or English corrections.).

Keywords

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Last update: 1 October 2008

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