Special Issue "Natural Product Pre-fractionation"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (30 May 2008)
Dr. John A. Beutler
Molecular Targets Laboratory, Bldg 560-1, Room 11-74A, Frederick National Laboratory for Cancer Research, Frederick, MD 21702-1201, USA
Phone: +1 301 846 1942
Fax: +1 301 846 6177
Interests: natural products; cancer; HIV; plants; molecular targets
Natural products provide an unparalleled source of chemical diversity for discovery of important and interesting biologically active molecules. This bounty comes at a price, since crude extracts of natural products can be difficult to screen in bioassays, and must be fractionated with guidance from the bioassay to obtain pure compounds. If the active compounds are present in trace amounts this can become a very difficult and time-consuming process, or the activity may be missed altogether. Numerous companies and academic groups have therefore sought to remedy these problems by chromatographically separating the extract to various degrees of resolution. This issue will examine a spectrum of different approaches and provide details on the technical challenges involved, the costs, and the rewards in improved identification of novel natural products.
Dr. John A. Beutler
- Eldridge, G. R.; Vervoort, H. C.; Lee, C. M.; Cremin, P. A.; Williams, C. T.; Hart, S. M.; Goering, M. G.; O'Neil-Johnson, M.; Zeng, L. High-throughput method for the production and analysis of large natural product libraries for drug discovery. Anal.Chem. 2002, 74 (16), 3963-3971.
- Bindseil, K. U.; Jakupovic, J.; Wolf, D.; Lavayre, J.; Leboul, J.; van der Pyl, D. Pure compound libraries; a new perspective for natural product based drug discovery. Drug Discov. Today 2001, 6 (16), 840-847.
Article: Pre-fractionated Microbial Samples – The Second Generation Natural Products Library at Wyeth
Molecules 2008, 13(6), 1406-1426; doi:10.3390/molecules13061406
Received: 30 May 2008; Accepted: 16 June 2008 / Published: 20 June 2008| Download PDF Full-text (487 KB)
Molecules 2008, 13(6), 1372-1383; doi:10.3390/molecules13061372
Received: 3 June 2008; in revised form: 18 June 2008 / Accepted: 18 June 2008 / Published: 19 June 2008| Download PDF Full-text (283 KB)
Last update: 27 February 2014