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Molecules 2008, 13(6), 1406-1426; doi:10.3390/molecules13061406

Pre-fractionated Microbial Samples – The Second Generation Natural Products Library at Wyeth

Natural Products Discovery Research, Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, New York 10965, USA
Received: 30 May 2008 / Accepted: 16 June 2008 / Published: 20 June 2008
(This article belongs to the Special Issue Natural Product Pre-fractionation)
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Abstract

From the beginning of the antibiotic era in the 1940s to the present, Wyeth has sustained an active research program in the area of natural products discovery. This program has continually evolved through the years in order to best align with the “current” drug discovery paradigm in the pharmaceutical industry. The introduction of highthroughput screening and the miniaturization of assays have created a need to optimize natural product samples to better suit these new technologies. Furthermore, natural product programs are faced with an ever shortening time period from hit detection to lead characterization. To address these issues, Wyeth has created a pre-fractionated natural products library using reversed-phase HPLC to complement their existing library of crude extracts. The details of the pre-fractionated library and a cost-benefit analysis will be presented in this review. View Full-Text
Keywords: Natural products; pre-fractionated libraries; high-throughput screening; drug discovery; pharmaceutical industry Natural products; pre-fractionated libraries; high-throughput screening; drug discovery; pharmaceutical industry
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Wagenaar, M.M. Pre-fractionated Microbial Samples – The Second Generation Natural Products Library at Wyeth. Molecules 2008, 13, 1406-1426.

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