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Fractionated Marine Invertebrate Extract Libraries for Drug Discovery
Department of Medicinal Chemistry, University of Utah, 30 S. 2000 E. RM 307, Salt Lake City, UT 84112, USA
* Author to whom correspondence should be addressed.
Received: 3 June 2008; in revised form: 18 June 2008 / Accepted: 18 June 2008 / Published: 19 June 2008
Abstract: The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final method used HP20SS as a solid support to effectively desalt extracts and fractionate the organic components. Additionally, methods to integrate an automated LCMS fractionation approach to shorten discovery time lines have been implemented.
Keywords: Sponge; Tunicate; Prefractionation; HP20SS; Marine Natural Products; LCMS.
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MDPI and ACS Style
Bugni, T.S.; Harper, M.K.; McCulloch, M.W.; Reppart, J.; Ireland, C.M. Fractionated Marine Invertebrate Extract Libraries for Drug Discovery. Molecules 2008, 13, 1372-1383.
Bugni TS, Harper MK, McCulloch MW, Reppart J, Ireland CM. Fractionated Marine Invertebrate Extract Libraries for Drug Discovery. Molecules. 2008; 13(6):1372-1383.
Bugni, Tim S.; Harper, Mary K.; McCulloch, Malcolm W.; Reppart, Jason; Ireland, Chris M. 2008. "Fractionated Marine Invertebrate Extract Libraries for Drug Discovery." Molecules 13, no. 6: 1372-1383.