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Molecules 2008, 13(6), 1372-1383; doi:10.3390/molecules13061372
Article

Fractionated Marine Invertebrate Extract Libraries for Drug Discovery

, , ,  and *
Received: 3 June 2008; in revised form: 18 June 2008 / Accepted: 18 June 2008 / Published: 19 June 2008
(This article belongs to the Special Issue Natural Product Pre-fractionation)
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Abstract: The high-throughput screening and drug discovery paradigm has necessitated a change in preparation of natural product samples for screening programs. In an attempt to improve the quality of marine natural products samples for screening, several fractionation strategies were investigated. The final method used HP20SS as a solid support to effectively desalt extracts and fractionate the organic components. Additionally, methods to integrate an automated LCMS fractionation approach to shorten discovery time lines have been implemented.
Keywords: Sponge; Tunicate; Prefractionation; HP20SS; Marine Natural Products; LCMS. Sponge; Tunicate; Prefractionation; HP20SS; Marine Natural Products; LCMS.
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Bugni, T.S.; Harper, M.K.; McCulloch, M.W.; Reppart, J.; Ireland, C.M. Fractionated Marine Invertebrate Extract Libraries for Drug Discovery. Molecules 2008, 13, 1372-1383.

AMA Style

Bugni TS, Harper MK, McCulloch MW, Reppart J, Ireland CM. Fractionated Marine Invertebrate Extract Libraries for Drug Discovery. Molecules. 2008; 13(6):1372-1383.

Chicago/Turabian Style

Bugni, Tim S.; Harper, Mary K.; McCulloch, Malcolm W.; Reppart, Jason; Ireland, Chris M. 2008. "Fractionated Marine Invertebrate Extract Libraries for Drug Discovery." Molecules 13, no. 6: 1372-1383.



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