Special Issue "Phospholipids"

Guest Editor
Dr. David Leo Daleke
Medical Sciences Program, Bloomington and- Department of Biochemistry and Molecular Biology- Indiana University School of Medicine-- Bloomington, Indiana 47405, USA
E-Mail:
Interests: phospholipid metabolism and synthesis, phospholipid transbilayer asymmetry, phospholipid domains, novel phospholipids, phospholipid-protein interactions, phospholipids in signalling, phospholipid biophysics, phospholipid structure and function, vesicular and non-vesicular phospholipid trafficking, transbilayer phospholipid transport, phospholipids in disease

Submission

All papers should be submitted to molecules@mdpi.org with copy to the guest editor. To be published continuously until the deadline and papers will be listed together at the special websites.

Submitted papers should not have been previously published nor be currently under consideration for publication elsewhere. All papers are refereed through a peer review process. A guide for authors, sample copies and other relevant information for submitting papers are available on the Instructions for Authors page. Molecules is an international peer-reviewed monthly journal published by Molecular Diversity Preservation International.

Please visit the Instructions for Authors page before submitting a paper. Open Access publication fees are 800 CHF per paper. English correction fees (250 CHF) will be added in certain cases (1050 CHF per paper for those papers that require extensive additional formatting and/or English corrections).

• phospholipid metabolism and synthesis
• phospholipid transbilayer asymmetry
• phospholipid domains
• novel phospholipids
• phospholipid-protein interactions
• phospholipids in signalling
• phospholipid biophysics
• phospholipid structure and function
• vesicular and non-vesicular phospholipid trafficking
• transbilayer phospholipid transport
• phospholipids in disease

Manuscript ID: Molecules-Phospholipids 20090504-us- Zeineldin
Type of Paper: Review
Title: Biomimetic Silica Microspheres in Biosensing
Author: Reema Zeineldin
Affiliation: College of Pharmacy, University of New Mexico, MSC09 5360, Albuquerque, NM 87131; Email: reemaz@salud.unm.edu
Abstract: Lipid vesicles spontaneously fuse and assemble into a lipid bilayer on planar or spherical silica surfaces and other substrates. The supported lipid bilayer (SLB) maintains the characteristics of biological membranes, and are thus considered to be biomembrane mimetic systems that are stable because of the underlying substrate. Examples their shared characteristics with biomembranes include lateral fluidity, barrier formation to ions and molecules, and their ability to incorporate membrane proteins into them. Biomimetic silica microspheres consisting of SLBs on solid or porous silica microspheres are employed for different biosensing applications. The advantages of such biomimetic microspheres for biosensing include their increased surface area to volume ratio which improves the detection limits of analytes, and they are amenable for miniaturization, multiplexing and high throughput screening. This review presents examples and formats of using biomimetic solid or porous silica microspheres in biosensing.
Keywords: solid microsphere, porous microspheres, supported lipid bilayer, fluorescence, superquenching, flow cytometry, microfluidic, suspension assay, drug partitioning, ligand-receptor interaction, membrane active agents