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Special Issue "Current Advances in Phosphate Bioisosters and Mimics"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: 31 May 2019

Special Issue Editors

Guest Editor
Prof. Thomas Poisson

Normandie University, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France
Institut Universitaire de France, 1 rue Descartes, 75231 Paris, France
Website | E-Mail
Interests: development of new methods for organic synthesis; fluorinated molecules; metal catalyzed reactions; glycomimetics; carbohydrates; asymmetric catalysis
Guest Editor
Prof. Xavier Pannecoucke

Normandie University, INSA Rouen, UNIROUEN, CNRS, COBRA (UMR 6014), 76000 Rouen, France
Website | E-Mail
Interests: development of new methods for organic synthesis; fluorinated molecules; glycomimetics; carbohydrates; asymmetric synthesis

Special Issue Information

Dear Colleagues,

The phosphate function is of high importance in a plethora of biological events. For instance, phosphates are involved in regulation of the kinase activity or nucleic acid replication. Therefore, the design of phosphate-based drugs has become an attractive strategy. However, the development of biological active-phosphate-containing molecules is still challenging due to the enzymatic lability of this residue in vivo and the poor cellular penetration of the charged phosphate. To overcome these limitations the implementation of bioisosters and mimics is an appealing strategy to open new avenues for the discovery of new bioactive molecules and drugs. In this Special Issue, we will highlight the recent progress made in the field of phosphate biosisosters and mimics. We welcome contributions that describe new progress in the synthesis of phosphate bioisosters or mimics, newly designed bioisosters, and new applications of these mimics in the quest for bioactive molecules. In addition, review articles from experts in the field will be considered.

We are looking forward receiving your submission.

Prof. Thomas Poisson
Prof. Xavier Pannecoucke
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioisosters
  • phosphorus chemistry
  • fluorine chemistry
  • bioactive molecules
  • new methodology
  • catalysis
  • carbohydrates
  • chemical biology
  • medicinal chemistry
  • drug discovery
  • nucleosides
  • organic synthesis

Published Papers

This special issue is now open for submission.
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