Special Issue "Olefin Metathesis and Its Application"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: closed (31 March 2012)
Dr. Anna G. Wenzel
Joint Science Department, Claremont McKenna, Pitzer and Scripps Colleges, Claremont, California 91711, USA
Interests: asymmetric catalysis; organometallic cemistry; organic synthesis
The reliable and efficient generation of carbon-carbon bonds underpins the foundation of chemical synthesis. Of these, olefin metathesis has risen to the forefront of the methods utilized for the preparation of alkenes. Catalyst developments in the past 25 years have dramatically increased the accessibility of this reaction for general use, with many catalysts now being commercially available. In addition, significant progress has been made in understanding the catalyst and substrate structural features, their interactions, and experimental conditions crucial to reaction selectivity. This has led to numerous applications of olefin metathesis in both academia and industry. In particular, cross-metathesis, ring-closing metathesis, enyne metathesis, ring-rearrangement metathesis, as well as tandem processes, remain highly active areas of investigation.
Despite the progress that has been achieved, many challenges remain, principally with regard to catalyst stability and control. The issue of control manifests itself in a myriad of ways, be it regiochemical or stereochemical. For example, the issue of olefin diastereocontrol in metathesis remains a significant challenge due to the thermodynamic nature of the reaction. Additionally, the pursuit of substrate control, while maintaining high catalyst turnover numbers in the face of steric and electronic impediments, remains a significant goal of catalyst design. Fortunately, recent years have seen many elegant solutions towards progress in overcoming these hurdles.
This Special Issue on olefin metathesis will offer an attractive forum to present recent results in olefin metathesis pertaining to catalyst development, broadened substrate scope and/or stereocontrol, as well as the application of olefin metathesis to synthesis. I strongly encourage authors to submit papers for Molecules’ Special Issue on Olefin Metathesis. I believe that the topics covered will thoroughly convey the expanding potential and applicability of this versatile reaction.
Dr. Anna G. Wenzel
- olefin metathesis
- transition metal
Molecules 2011, 16(8), 6871-6882; doi:10.3390/molecules16086871
Received: 4 May 2011; in revised form: 8 July 2011 / Accepted: 12 July 2011 / Published: 11 August 2011| Download PDF Full-text (443 KB)
Review: One Step Formation of Propene from Ethene or Ethanol through Metathesis on Nickel Ion-loaded Silica
Molecules 2011, 16(9), 7844-7863; doi:10.3390/molecules16097844
Received: 30 June 2011; in revised form: 4 August 2011 / Accepted: 5 September 2011 / Published: 13 September 2011| Download PDF Full-text (1975 KB)
Molecules 2012, 17(3), 3348-3358; doi:10.3390/molecules17033348
Received: 28 February 2012; in revised form: 7 March 2012 / Accepted: 13 March 2012 / Published: 15 March 2012| Download PDF Full-text (463 KB)
Communication: Synthesis of Electronically Modified Ru-Based Neutral 16 VE Allenylidene Olefin Metathesis Precatalysts
Molecules 2012, 17(5), 5177-5186; doi:10.3390/molecules17055177
Received: 1 April 2012; in revised form: 25 April 2012 / Accepted: 26 April 2012 / Published: 4 May 2012| Download PDF Full-text (359 KB)
Article: Development of a Method for the Preparation of Ruthenium Indenylidene-Ether Olefin Metathesis Catalysts
Molecules 2012, 17(5), 5675-5689; doi:10.3390/molecules17055675
Received: 28 March 2012; in revised form: 18 April 2012 / Accepted: 23 April 2012 / Published: 11 May 2012| Download PDF Full-text (345 KB)
Article: Metathesis Transformations of Natural Products: Cross-Metathesis of Natural Rubber and Mandarin Oil by Ru-Alkylidene Catalysts
Molecules 2012, 17(5), 6001-6010; doi:10.3390/molecules17056001
Received: 16 March 2012; in revised form: 30 April 2012 / Accepted: 3 May 2012 / Published: 18 May 2012| Download PDF Full-text (245 KB)
Last update: 4 March 2014